Xanthones and benzophenones isolated from the endophytic fungus Penicillium sp. ct-28 of Corydlis tomentella and their cytotoxic activity
| Autor: | Qianliang Ming, Yunong Li, Xiuxing Jiang, Xiuning Huang, Yimo He, Lingyue Qin, Yanxia Liu, Yu Tang, Ning Gao |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Magnetic Resonance Spectroscopy Dose-Response Relationship Drug Molecular Structure Xanthones Cell Cycle Penicillium Apoptosis General Medicine Hep G2 Cells Benzophenones Inhibitory Concentration 50 Structure-Activity Relationship Corydalis Cell Line Tumor Drug Discovery Humans Cell Proliferation |
| Zdroj: | Fitoterapia. 157 |
| ISSN: | 1873-6971 |
| Popis: | One new xanthone, griseophenexanthone A (1), one new benzophenone, digriseophene A (2), and 14 previously reported compounds were isolated from the culture of Penicillium sp. ct-28, an endophytic fungus of Corydlis tomentella. The structures of the isolated compounds were identified by an extensive analysis of HRESIMS, 1D and 2D NMR. MTT assay showed that six xanthones (1 and 3-7) significantly inhibited cell proliferation in four cancer cell lines, with IC |
| Databáze: | OpenAIRE |
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