Contingency management treatment for methamphetamine use disorder in South Africa
| Autor: | Steve Shoptaw, Chukwuemeka N. Okafor, Jonathan C Ipser, Edythe D. London, Lara J van Nunen, Lisa Dannatt, Tamar Krishnamurti, Dan J. Stein, Marilyn T Lake |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Health (social science) media_common.quotation_subject Amphetamine-Related Disorders 030508 substance abuse Medicine (miscellaneous) Contingency management Context (language use) Medical and Health Sciences Article Methamphetamine 03 medical and health sciences South Africa 0302 clinical medicine contingency management Clinical Research Behavior Therapy Cape medicine Humans Mass index 030212 general & internal medicine media_common behavioural treatment business.industry Prevention Psychology and Cognitive Sciences Neurosciences methamphetamine use disorder Substance Abuse Abstinence Middle Aged Brain Disorders Good Health and Well Being Studies in Human Society stimulants Household income Median body Female 0305 other medical science business medicine.drug Demography |
| Zdroj: | Drug and alcohol review, vol 39, iss 3 Drug Alcohol Rev |
| Popis: | Author(s): Okafor, Chukwuemeka N; Stein, Dan J; Dannatt, Lisa; Ipser, Jonathan; van Nunen, Lara J; Lake, Marilyn T; Krishnamurti, Tamar; London, Edythe D; Shoptaw, Steve | Abstract: Introduction and aimsAs South Africa, especially the Western Cape Province, faces an epidemic of methamphetamine use disorder, therapeutic approaches suited to the South African context are needed. This secondary analysis assessed retention and methamphetamine abstinence outcomes in response to an 8-week pilot contingency management (CM) intervention trial of neural correlates of methamphetamine abstinence, exploring sociodemographic and clinical differences between responders and non-responders.Design and methodsResearch participants provided thrice-weekly monitored urine samples, which were analysed by qualitative radioimmunoassay. The primary outcome for this analysis was therapeutic response, defined as abstinence from methamphetamine (≥23 of 24 possible methamphetamine-negative urine samples).ResultsData from 30 adults living in Cape Town, South Africa (34 ± 6.1 years of age, mean age ± SD, 21 men) were included. Sixty-three percent (12 men) were responders. In bivariate comparisons, baseline measurements showed fewer responders reported monthly household income ≥25 000+ South African Rand (ZAR; ~USD $1880; vs. ZAR l 25 000) than non-responders (15.8% vs. 63.6%; P = 0.007). Furthermore, responders had higher median years of education (12 vs. 10; Kruskal-Wallis χ2 = 4.25, DF = 1, P = 0.039) and lower median body mass index than non-responders (19 vs. 24; Kruskal-Wallis χ2 = 6.84, P = 0.008).Discussion and conclusionsTherapeutic response in this study were comparable to those obtained with CM for methamphetamine use disorder in North America and Europe. Our findings suggest that CM may be a useful component of treatment strategies to boost retention and continuous abstinence from methamphetamine in Cape Town, South Africa. Larger efficacy studies are needed in this setting. |
| Databáze: | OpenAIRE |
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