Investigation of the Relationship Between Fok1 and Col1A1 Gene Polymorphisms and Development of Treatment-Related Bone Complications in Children with Acute Lymphoblastic Leukemia
| Autor: | Hale Ören, Özlem Tüfekçi, Deniz Kızmazoğlu, Şebnem Yılmaz, Berna Eroğlu Filibeli, Sefa Kizildag, Melek Erdem |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine lcsh:Internal medicine medicine.medical_specialty medicine.medical_treatment Osteoporosis Acute lymphoblastic leukemia Gastroenterology Calcitriol receptor Collagen Type I vitamin D deficiency Bone remodeling 03 medical and health sciences 0302 clinical medicine Bone Density Internal medicine Bone mineral density medicine Genetic predisposition Humans Genetic Predisposition to Disease Child lcsh:RC31-1245 Bone mineral Chemotherapy Polymorphism Genetic Genetic polymorphism lcsh:RC633-647.5 business.industry Infant Newborn Osteonecrosis Infant lcsh:Diseases of the blood and blood-forming organs Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Collagen Type I alpha 1 Chain 030104 developmental biology Child Preschool 030220 oncology & carcinogenesis Receptors Calcitriol Female Gene polymorphism business Research Article |
| Zdroj: | Turkish Journal of Hematology, Vol 36, Iss 1, Pp 12-18 (2019) Turkish Journal of Hematology |
| ISSN: | 1300-7777 |
| Popis: | In acute lymphoblastic leukemia (ALL), various clinical risk factors and genetic predispositions contribute to the development of bone complications during and after chemotherapy. In this study, we aimed to investigate whether vitamin D receptor (Fifty children with ALL who were treated with the ALL Berlin-Frankfurt-Muenster-95 protocol between 1998 and 2008 and were followed for at least 7 years were enrolled. The control group consisted of 96 healthy children.Low BMD (16%), osteoporosis (12%), and osteonecrosis (8%) were present in a total of 18 patients (36%). The frequency of osteonecrosis and total bone abnormalities was significantly higher in children aged ≥10 years (p=0.001). The risk of low BMD and osteonecrosis was higher in those with vitamin D deficiency. Only theThe development of therapy-induced bone mineral loss and osteonecrosis in children with ALL is frequent and the risk is especially higher in children aged ≥10 years and with vitamin D deficiency. The association betweenAkut lenfoblastik lösemide (ALL), çeşitli klinik risk faktörleri ve genetik yatkınlıklar kemoterapi sırasında ve sonrasında kemik komplikasyonlarının gelişmesine katkıda bulunur. Bu çalışmada, kemik mineral ve matriks oluşumunda önemli olan D vitamini reseptörü (1998-2008 yılları arasında ALL tanısı alıp, ALL Berlin-Frankfurt-Muenster-95 protokolü ile tedavi edilen ve en az 7 yıl takip edilen 50 çocuk çalışmaya dahil edildi. Kontrol grubu 96 sağlıklı çocuktan oluşuyordu.Toplam 18 hastada (%36) düşük KMY (%16), osteoporoz (%12) ve osteonekroz (%8) mevcuttu. Osteonekroz sıklığı ve toplam kemik anormallikleri 10 yaş ve üstü çocuklarda anlamlı olarak yüksek bulundu (p=0,001). D vitamini eksikliği olanlarda düşük BMD ve osteonekroz riski daha yüksekti. Gen polimorfizmleri ile ilişki incelendiğinde; sadeceSonuç olarak, ALL’den sağ kalan çocuklarda tedaviye bağlı kemik mineral kaybı ve osteonekroz gelişimi sıktır ve bu risk özellikle 10 yaş ve üstü D vitamini eksikliği olan çocuklarda daha yüksektir. |
| Databáze: | OpenAIRE |
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