Regulation of sulfate metabolism in Neurospora crassa: Transport and accumulation of glucose 6-sulfate
| Autor: | George A. Marzluf, William R. Reinert |
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| Rok vydání: | 1974 |
| Předmět: |
Time Factors
Biological Transport Active Biology Sulfur Radioisotopes Biochemistry Neurospora Choline Neurospora crassa Methionine Genes Regulator Genetics Extracellular Electrophoresis Paper Molecular Biology Alleles Ecology Evolution Behavior and Systematics chemistry.chemical_classification Sulfates Permease Sulfatase Membrane Transport Proteins General Medicine Metabolism biology.organism_classification Sulfate transport Glucose Enzyme chemistry Mutation Enzyme Repression Sulfatases |
| Zdroj: | Biochemical Genetics. 12:97-108 |
| ISSN: | 1573-4927 0006-2928 |
| Popis: | Neurospora crassa can utilize glucose 6-sulfate as its sole sulfur source, although this compound cannot serve as a carbon source for this organism. Neurospora possesses a transport system capable of glucose 6-sulfate uptake; the system is energy dependent, is inhibited by extracellular sulfate, and is clearly distinct from the permeases responsible for the uptake of glucose and those for sulfate transport. The metabolism of glucose 6-sulfate apparently involves its transport as an intact molecule, followed by a slow intracellular hydrolysis. Methionine, which represses the synthesis of a number of enzymes of sulfur anabolism, also represses the synthesis of the transport system responsible for glucose 6-sulfate uptake. A regulatory gene, cys-3, which controls the synthesis of aryl sulfatase, choline sulfatase, choline-O-sulfate permease, and two distinct permease species, also regulates the permease for glucose 6-sulfate. |
| Databáze: | OpenAIRE |
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