Neuroendocrine and amine studies in affective illness
| Autor: | Regina C. Casper, John M. Davis, Haroutune Dekirmenjian, Ghanshyam N. Pandey, David L. Garver |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Blood Glucose
Male Biogenic Amines medicine.medical_specialty Apomorphine Endocrinology Diabetes and Metabolism Urinary system Hypoglycemia Growth hormone Methoxyhydroxyphenylglycol Excretion Endocrinology Postsynaptic potential Internal medicine medicine Humans Insulin Affective Symptoms Biological Psychiatry Neurotransmitter Agents Endocrine and Autonomic Systems Insulin tolerance test medicine.disease Psychiatry and Mental health Anti-Anxiety Agents Dopamine receptor Growth Hormone Schizophrenia Female medicine.symptom Psychology Mania |
| Zdroj: | Psychoneuroendocrinology. 2:105-113 |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/0306-4530(77)90016-6 |
| Popis: | SUMMARY (1) There are limitations to some of these studies because of the small number of patients involved, but our data suggest that maximal Growth Hormone (GH) levels after induced hypoglycemia were lower in depressed patients than in control subjects. (2) Manic patients showed low GH peaks during the Insulin Tolerance Test (ITT), and furthermore urinary 3-methoxy-4-hydroxyphenylene glycol (MHPG) excretion rates in mania were indistinguishable from normals but higher than in depressed patients. (3) The apomorphine-induced GH response was essentially normal in affective disorder patients, while acute schizophrenic patients showed hypersensitivity of postsynaptic dopamine receptors. (4) Confirming previous studies by Maas et aL (1968, 1972), patients with depressive illness were found to have siguicantly lower urinary MHPG excretion, whereas borderline patients with depressive symptomatology had MHPG values similar to control subjects. |
| Databáze: | OpenAIRE |
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