Anti-mitotic properties of resveratrol analog (Z)-3,5,4′-trimethoxystilbene
Autor: | Raymond Brouillard, André Fougerousse, Philippe Chabert |
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Rok vydání: | 2006 |
Předmět: |
Stereochemistry
Clinical Biochemistry Rheum undulatum Mitosis Stereoisomerism Resveratrol Biochemistry chemistry.chemical_compound Tubulin Stilbenes Humans Cell Proliferation Virola cuspidata Electrophoresis Agar Gel Dose-Response Relationship Drug biology Cell Cycle General Medicine Flow Cytometry biology.organism_classification Antineoplastic Agents Phytogenic Tubulin Modulators chemistry Caco-2 Polyphenol Virola elongata Colonic Neoplasms biology.protein Molecular Medicine Caco-2 Cells |
Zdroj: | BioFactors. 27:37-46 |
ISSN: | 1872-8081 0951-6433 |
DOI: | 10.1002/biof.5520270104 |
Popis: | (Z)-3,5,4'-Trimethoxystilbene is a natural polyphenol present in five different plants, Virola cuspidata, Virola elongata, Centipeda minima, Schoenus nigricans and Rheum undulatum. This molecule was prepared in a three-step sequence in good overall yield. The isomerisation from the (E)- to (Z)-isomer is performed using UV irradiation. Biological investigations were conducted on a human colon cancer cell line (Caco-2) with anti-mitotic activities. Growth was completely arrested at an added 0.4 microM level of (Z)-3,5,4'-trimethoxystilbene. This agent is 100-fold more active than resveratrol or (E)-3,5,4'-trihydroxystilbene, and the mechanism of this process involves an inhibition of tubulin polymerisation in a dose dependent manner. |
Databáze: | OpenAIRE |
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