HCV genotypes in Northern Italy: a survey of 1368 histologically proven chronic hepatitis C patients
| Autor: | Gianni Rinaldi, Eliseo Minola, Paolo Riboli, Alberto Piperno, Fabio Panizzuti, Alessandra Ricci, Luigi Roffi, Marco Buonocore, Roberto Ceriani, Giovanni Fornaciari, Angelo Sangiovanni, Maria Cristina Nava, Pietro Pioltelli, Giuseppe Mancia, Carlo Donada, Bruno Paris, Astrid Scalori, Paolo Del Poggio, Massimo Pozzi, Cristina Ogliari, Rino Morales, Valentina Bellia, Guido Colloredo |
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| Přispěvatelé: | Roffi, L, Ricci, A, Ogliari, C, Scalori, A, Minola, E, Colloredo, G, Donada, C, Ceriani, R, Rinaldi, G, Paris, B, Fornaciari, G, Morales, R, Del Poggio, P, Sangiovanni, A, Buonocore, M, Bellia, V, Riboli, P, Nava, M, Panizzuti, F, Piperno, A, Pozzi, M, Pioltelli, P, Mancia, G |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood transfusion Cirrhosis Adolescent medicine.medical_treatment Hepatitis C virus Hepacivirus Genome Viral Disease medicine.disease_cause Internal medicine Epidemiology Genotype medicine Humans Aged Aged 80 and over Hepatology business.industry Confounding Genetic Variation Middle Aged Hepatitis C Chronic medicine.disease Virology Italy Female Viral disease business Human |
| Zdroj: | Journal of Hepatology. 29:701-706 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/s0168-8278(98)80249-3 |
| Popis: | Background/Aims: Hepatitis C virus (HCV) easily undergoes genomic changes, thus accounting for the presence of different genotypes, with different geographic distributions and different outcomes of chronic hepatitis. Type 1b is frequently found in advanced diseases; however, since this genotype is the most prevalent in older patients, the association with advanced age and severity of the disease is confounding. The aim of this study was to assess changes in the prevalence of HCV genotypes by surveying a large population of chronic hepatitis C patients in Northern Italy, and to assess if the high prevalence of genotye 1b in older patients with advanced diseases simply reflects the duration of HCV infection, rather than intrinsic biological properties of HCV. Methods: We studied 1368 HCV-RNA positive patients, with histologically proven chronic hepatitis. Drug addiction, blood transfusions and sporadically acquired infections represented the risk factors Results: Genotype 1b, the most prevalent isolate, and genotype 2a were associated with older age, cirrhosis, sporadically-acquired infections and blood transfusion, while types 1a, 3a, and 4 were associated with younger age, chronic persistent hepatitis and drug addiction. Patients with a history of transfusion were divided into four groups depending on the period of transfusion. The prevalence of genotype 1b decreased with time. Type 3a appeared only after 1979. Conclusions: The severity of chronic hepatitis C could be related more to the duration of the infection rather than to the intrinsic pathogenicity of HCV genotypes |
| Databáze: | OpenAIRE |
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