Digital Ischemia in Patients with Solid Tumors: a Case Report and Review of the Literature

Autor:	Roberto Moretto, Elide Matano, Chiara Carlomagno, Lucia Raimondo, Chiara Alessandra Cella
Přispěvatelé:	Raimondo, Lucia, Cella, CHIARA ALESSANDRA, Moretto, Roberto, Matano, Elide, Carlomagno, Chiara
Rok vydání:	2011
Předmět:	Pathology medicine.medical_specialty business.industry Colorectal cancer Ischemia Vasospasm paraneoplastic syndrome medicine.disease Thrombosis Oxaliplatin Capecitabine breast cancer Breast cancer colon cancer medicine digital ischemia Arteritis business medicine.drug
Zdroj:	Journal of Cancer Therapy. :281-284
ISSN:	2151-1942 2151-1934
DOI:	10.4236/jct.2011.22036
Popis:	Digital ischemia is a rare paraneoplastic phenomenon associated with various malignancies, especially adenocarci-nomas. We reported a case of digital ischemia onset during treatment with capecitabine + oxaliplatin, letrozole and epoetin-beta in a 75-year old woman with colon and breast cancer and a secondary hepatic lesion. A literature review disclosed 68 cases of solid neoplasms associated with digital ischemia. The proposed mechanisms of such clinical manifestations are various: vasospasm due to sympathetic hyperactivity, arteritis induced by tumour antigen-antibody complexes deposition or as consequence of immune deregulation, blood hyperviscosity, hypercoagulability or peripheral thrombosis. In the present case, clinical and laboratory evaluations failed to reveal evidence of thrombosis, arteritis, inherited or acquired hypercoagulable state and we postulated the peripheral vasospasm and the sympathetic activity (possibly due to chemotherapy drugs) as potential causes of the digital ischemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2301087b45a94bcd338ead71f7785085 https://doi.org/10.4236/jct.2011.22036 Zobrazit plný text záznamu