Altered Clinical Course of Malignant Melanoma in HIV-Positive Patients
| Autor: | Barbara J. Klencke, Mehdi Nosrati, Richard I. Crawford, Lori K. E. Rodrigues, Mohammed Kashani-Sabet, Timothy G. Berger, James R. Miller, Carlos M. M. Ferreira, Kirsten Vin-Christian |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Skin Neoplasms Dermatology Disease Severity of Illness Index Asymptomatic Disease-Free Survival Statistics Nonparametric Cohort Studies Age Distribution Acquired immunodeficiency syndrome (AIDS) Reference Values Risk Factors HIV Seronegativity Immunopathology Internal medicine HIV Seropositivity medicine Humans Sex Distribution Melanoma Aged Neoplasm Staging Probability Retrospective Studies business.industry Biopsy Needle virus diseases Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Survival Rate Case-Control Studies Immunology Disease Progression Female Viral disease medicine.symptom business Cohort study |
| Zdroj: | Archives of Dermatology. 138:765 |
| ISSN: | 0003-987X |
| DOI: | 10.1001/archderm.138.6.765 |
| Popis: | Objective To determine whether the natural history of melanoma is different in patients who test positive for human immunodeficiency virus (HIV) compared with matched control subjects. Design Retrospective cohort analysis. Setting Ambulatory care at 2 university-affiliated medical centers. Patients Each HIV-positive melanoma patient (n = 17) was randomly matched with 2 HIV-negative patients (HIV status unknown, but without risk factors for HIV) based on the melanoma subtype, tumor thickness, Clark level, tumor location, and sex and age of the patient. Main Outcome Measures Disease-free survival and overall survival of HIV-positive and HIV-negative melanoma patients were compared using a matched-pairs analysis. CD4 cell counts were recorded at the time of melanoma diagnosis and disease recurrence. Results Melanoma patients who were HIV positive had a significantly shorter disease-free survival ( P = .03) and overall survival ( P = .045) compared with HIV-negative melanoma patients by matched-pairs analysis. There was an inverse relationship between CD4 cell counts and time to first melanoma recurrence. Conclusions The natural history of malignant melanoma in HIV-positive patients is more aggressive compared with matched HIV-negative melanoma patients. Altered immune response and comorbid disease may play a role in the poor clinical outcome of HIV-positive patients. These findings have important implications in the management of melanoma in the setting of HIV disease. |
| Databáze: | OpenAIRE |
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