Age‐Related Increase in the Frequency of CD4+T Cells That Produce Interferon‐γ in Response to Staphylococcal Enterotoxin B during Childhood
| Autor: | Linda L. Yasukawa, Barbara Sullivan, Ann M. Arvin, Mimi Fang, Phillip Sung, Mary Rinki, Rima Hanna-Wakim, Ross DeHovitz, Hayley A. Gans |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte CD4-Positive T-Lymphocytes Male Adolescent medicine.medical_treatment T cell CD40 Ligand chemical and pharmacologic phenomena Enterotoxins Interferon-gamma Young Adult Immune system Antigen Antigens CD Interferon medicine Humans Immunology and Allergy Lectins C-Type Interferon gamma Child CD40 biology Age Factors Infant hemic and immune systems T lymphocyte Flow Cytometry Lymphocyte Subsets Infectious Diseases Cytokine medicine.anatomical_structure Child Preschool Immunology biology.protein Leukocyte Common Antigens Female medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 200:1921-1927 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/648375 |
| Popis: | Background The susceptibility of infants to infections is well defined clinically, and immunologic abnormalities have been described. Immune maturation is complex, however, and the interval during which changes occur during childhood has not been identified. Methods To assess age-related differences in the CD4(+) T cell responses, we evaluated the frequency of CD4(+) T cells that produced interferon (IFN) gamma in response to staphylococcal enterotoxin B (SEB) stimulation in 382 healthy infants and children (2 months to 11 years of age) and 66 adults. Flow cytometry was used to assess SEB-induced CD69 and CD40 ligand (CD40-L) expression and IFN-gamma production by CD4(+) and CD45RO(+)CD4(+) T cells. Results CD69 and CD40-L expression by CD4(+) and CD45RO(+)CD4(+) T cells were similar to adult levels from infancy, but the frequency of activated T cells that produced IFN-gamma remained lower than adult responses until children were 10 years of age. Conclusions These observations indicate that the IFN-gamma response of CD4(+) T cells to SEB remains limited for a much longer interval than was reported elsewhere, extending to the second decade of life. Observed differences in CD45RO(+)CD4(+) T cell function indicate that CD4(+) T cells with the same phenotypes do not possess equivalent functional capabilities. |
| Databáze: | OpenAIRE |
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