Effects of the beta(2)-agonist clenbuterol on respiratory and limb muscles of weaning rats
| Autor: | Federica Boschi, B. Polla, Carlo Reggiani, F. Morello, V. Cappelli, M. A. Pellegrino, Ornella Pastoris |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Aging Physiology medicine.drug_class Phosphofructokinase-1 Diaphragm Muscle Fibers Skeletal Drinking Intercostal Muscles Hindlimb Biology Muscle Development Weight Gain Contractility Electron Transport Complex IV Myofibrils Physiology (medical) Internal medicine Respiratory muscle medicine Weaning Animals Clenbuterol Respiratory system Rats Wistar Muscle Skeletal Adenosine Triphosphatases Myosin Heavy Chains Muscle relaxant Adrenergic beta-Agonists Respiratory Muscles Diaphragm (structural system) Rats Endocrinology medicine.drug |
| Zdroj: | American journal of physiology. Regulatory, integrative and comparative physiology. 280(3) |
| ISSN: | 0363-6119 |
| Popis: | The aim of this study was to analyze the effects of chronic administration of the β2-agonist clenbuterol (1.5 mg · kg−1· day−1for 4 wk in the drinking water) on respiratory (diaphragm and parasternal intercostal) and hindlimb (tibialis and soleus) muscles in young rats during postnatal development (21 to 49 postnatal days).The treatment resulted in very little stimulation of muscle growth. Significant slow-to-fast transitions in the expression of myosin heavy chain isoforms and significant increases in the myofibrillar ATPase activity were found in the diaphragm and soleus, whereas tibialis anterior and intercostal muscles did not show any significant fiber-type alteration. Decrease of oxidative enzyme activities and increase of glycolytic enzyme activities were also observed.It is concluded that whereas the growth stimulation is age dependent and only detectable in adult rats, the fiber-type transformation is also present in weaning rats and particularly evident in the soleus and diaphragm. The fiber-type transformation caused by clenbuterol might lead to an enhancement of contractile performance and also to a reduced resistance to fatigue. |
| Databáze: | OpenAIRE |
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