Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples

Autor: Araceli Rosa, Evert Thiery, Tamara Sheinbaum, Jim van Os, Catherine Derom, Nele Jacobs, Marta de Castro-Catala, Thomas R. Kwapil, Ruud van Winkel, Neus Barrantes-Vidal, Elionora Peña, Martine van Nierop, Paula Cristóbal-Narváez
Přispěvatelé: Section Lifespan Psychology, RS-Research Line Lifespan psychology (part of IIESB program), Universitat de Barcelona
Rok vydání: 2016
Předmět:
Male
Val66met polymorphism
Childhood trauma
Methionine
0302 clinical medicine
Surveys and Questionnaires
Child Abuse
Child
Subclinical infection
Traumes psíquics
Valine
Middle Aged
Psychiatry and Mental health
Multiple factors
Female
Psychology
rs6265
Infància
Clinical psychology
Adult
Psychosis
medicine.medical_specialty
Adolescent
Genotype
Psicosi
Polymorphism
Single Nucleotide
Young Adult
03 medical and health sciences
Psychic trauma
Independent samples
Psychosis proneness
medicine
Psychotic experiences
Humans
Genetic Predisposition to Disease
Allele
Psychiatry
BDNF Val66Met
Biological Psychiatry
Psychiatric Status Rating Scales
Brain-Derived Neurotrophic Factor
Psychoses
medicine.disease
Childhood
Gene-environment interaction
030227 psychiatry
Psychotic Disorders
Risk allele
Gene-Environment Interaction
030217 neurology & neurosurgery
Zdroj: Journal of Psychiatric Research, 83, 121-129. Elsevier Ltd
Recercat. Dipósit de la Recerca de Catalunya
instname
de Castro-Catala, M, van Nierop, M, Barrantes-Vidal, N, Cristóbal-Narváez, P, Sheinbaum, T, Kwapil, T R, Peña, E, Jacobs, N, Derom, C, Thiery, E, van Os, J, van Winkel, R & Rosa, A 2016, ' Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples ', Journal of psychiatric research . https://doi.org/10.1016/j.jpsychires.2016.08.014
de Castro-Catala, M, van Nierop, M, Barrantes-Vidal, N, Cristóbal-Narváez, P, Sheinbaum, T, Kwapil, T, Pena, E, Derom, C, Thiery, E, van Os, J, van Winkel, R, Rosa, A & Jacobs, N E 2016, ' Childhood trauma, BDNF Val66Met and subclinical psychotic experiences : Attempt at replication in two independent samples ', Journal of Psychiatric Research, vol. 83, pp. 121-129 . https://doi.org/10.1016/j.jpsychires.2016.08.014
Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 0022-3956
DOI: 10.1016/j.jpsychires.2016.08.014
Popis: Childhood trauma exposure is a robust environmental risk factor for psychosis. However, not all exposed individuals develop psychotic symptoms later in life. The Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been suggested to moderate the psychosis-inducing effects of childhood trauma in clinical and nonclinical samples. Our study aimed to explore the interaction effect between childhood trauma and the BDNF Val66Met polymorphism on subclinical psychotic experiences (PEs). This was explored in two nonclinical independent samples: an undergraduate and technical-training school student sample (n = 808, sample 1) and a female twin sample (n = 621, sample 2). Results showed that childhood trauma was strongly associated with positive and negative PEs in nonclinical individuals. A BDNF Val66Met x childhood trauma effect on positive PEs was observed in both samples. These results were discordant in terms of risk allele: while in sample 1 Val allele carriers, especially males, were more vulnerable to the effects of childhood trauma regarding PEs, in sample 2 Met carriers presented higher PEs scores when exposed to childhood trauma, compared with Val carriers. Moreover, in sample 2, a significant interaction was also found in relation to negative PEs. Our study partially replicates previous findings and suggests that some individuals are more prone to develop PEs following childhood trauma because of a complex combination of multiple factors. Further studies including genetic, environmental and epigenetic factors may provide insights in this field.
Databáze: OpenAIRE
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