Aclidinium bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation
| Autor: | Hengjiang Zhao, Reynold A. Panettieri, Gautam Damera, Jose Freire, Homer W. Fogle, William Jester, Meiqi Jiang |
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| Rok vydání: | 2010 |
| Předmět: |
Antigens
Fungal medicine.drug_class Respiratory System Cell Count Cholinergic Antagonists Mice Pulmonary Disease Chronic Obstructive Airway resistance Aclidinium bromide Bronchodilator Leukocytes Respiratory Hypersensitivity Medicine Eosinophilia Animals Pulmonary Eosinophilia Bronchitis Asthma Pharmacology Inflammation COPD Mice Inbred BALB C medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal respiratory system Eosinophil medicine.disease respiratory tract diseases medicine.anatomical_structure Bronchoalveolar lavage Immunology Cytokines Female medicine.symptom business Bronchoalveolar Lavage Fluid Tropanes |
| Zdroj: | European journal of pharmacology. 649(1-3) |
| ISSN: | 1879-0712 |
| Popis: | Airway hyperresponsiveness and inflammation characterize the airways of individuals with asthma and chronic obstructive pulmonary disease (COPD). Hence, therapeutic approaches that attenuate such manifestations may offer promise in the management of these diseases. In the present study, we investigated whether a novel long-acting cholinergic antagonist, aclidinium bromide, modulates airway function and leukocyte trafficking in an Aspergillus fumigatus (Af)-induced murine model of asthma. Nebulized aclidinium (1 mg/ml) administration completely abrogated increases in methacholine-induced lung resistance in Af-exposed mice. Parallel assessment of dynamic compliance showed that aclidinium also completely restores methacholine-mediated decreases in naive and Af-exposed mice. As evidenced by differential cell counts within bronchoalveolar lavage fluid, aclidinium also diminished (51 ± 4%) Af-induced airway eosinophil numbers with no significant change in other immune cell types. Further assessment of cytokine and total protein levels in bronchoalveolar lavage fluid showed that aclidinium had little effect on IL-4 or IL-6 levels in either Af-exposed or naive mice but markedly decreased total protein levels in bronchoalveolar lavage fluid. These data suggest that aclidinium, a selective muscarinic antagonist, not only acts as a bronchodilator but could also act as an anti-inflammatory agent with potential clinical benefits in the treatment of COPD and asthma. |
| Databáze: | OpenAIRE |
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