Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
| Autor: | Kun Deng, Yong Zhang, Hong Liang, Haoran Ning, Zejun Wang, Huichuan Yang, He Yanlin, Li Cesheng, Li Taojing, Rong Zhou, Lin Lianzhen, Min Mao, Demei Dong, Xiaoming Yang, Peng Yan, Tao Du, Huanhuan Guo, Xia Zou, Ya Zhang, Wang Feifei, Yue Shenglan, Xinxin Zhang, Fengping Lu, Zhou Zhijun, Ding Yu, Yong Xie, Junzheng Wu, Hu Yong, Jianhong Yu, Xiao Wu, Lu Feng, Kai Duan, Daoxing Fu, Dongbo Zhou, Jia Lu, Yang Gao |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Convalescent plasma Coronavirus disease 2019 (COVID-19) media_common.quotation_subject Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science Adaptive immunity General Physics and Astronomy Article Antibodies General Biochemistry Genetics and Molecular Biology Immunoglobulin G 03 medical and health sciences 0302 clinical medicine Immune system Immunity Medicine Neutralizing antibody media_common Multidisciplinary biology business.industry Convalescence Antimicrobial responses General Chemistry Specific igg Titer 030104 developmental biology Immunization Viral infection Immunology biology.protein Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. The level of RBD-IgG decreases with time, with the titer stabilizing at 35.7% of the initial level by the 9th month. Moreover, male plasma donors produce more RBD-IgG than female, and age of the patients positively correlates with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers is also identified. These results facilitate our understanding of SARS-CoV-2-induced immune memory to promote vaccine and therapy development. COVID-19 pandemic is a global health risk, but our understanding on the induced durable immunity remains scarce. Here the authors assess antibody responses in 869 convalescent COVID-19 patients to find that specific antibody titers reduce with time, and the RBD-IgG positive rate exceed 70% at 12 month post diagnosis, with male and older patients showing stronger responses. |
| Databáze: | OpenAIRE |
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