Mass Drug Administration With High-Dose Ivermectin and Dihydroartemisinin-Piperaquine for Malaria Elimination in an Area of Low Transmission With High Coverage of Malaria Control Interventions: Protocol for the MASSIV Cluster Randomized Clinical Trial
| Autor: | Henk Broekhuizen, Christian Kositz, Koen Peeters Grietens, Steven W. Lindsay, Jane Achan, Joan Muela Ribera, Alexandra E. Fehr, Fatima Ceesay, Harouna M Soumare, Edgard Dabira, Teun Bousema, John S. Bradley, Chris Drakeley, Menno R. Smit, Claudia Nieto-Sanchez, Bakary Conteh, Umberto D'Alessandro, Balla Kandeh |
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| Přispěvatelé: | Athena Institute, Pediatric surgery, General Paediatrics, APH - Global Health |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Combination therapy Cluster randomized trial 030231 tropical medicine Computer applications to medicine. Medical informatics Psychological intervention R858-859.7 wc_765 wa_110 law.invention 03 medical and health sciences 0302 clinical medicine Dihydroartemisinin/piperaquine Randomized controlled trial SDG 3 - Good Health and Well-being law parasitic diseases Protocol qv_256 Medicine 030212 general & internal medicine Cluster randomised controlled trial Artemisinin Mass drug administration Ivermectin business.industry General Medicine medicine.disease The Gambia Malaria wc_750 lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Emergency medicine business medicine.drug Dihydroartemisinin-piperaquine |
| Zdroj: | JMIR Research Protocols Dabira, E D, Soumare, H M, Lindsay, S W, Conteh, B, Ceesay, F, Bradley, J, Kositz, C, Broekhuizen, H, Kandeh, B, Fehr, A E, Nieto-Sanchez, C, Ribera, J M, Grietens, K P, Smit, M R, Drakeley, C, Bousema, T, Achan, J & D'Alessandro, U 2020, ' Mass drug administration with high-dose ivermectin and dihydroartemisinin-piperaquine for malaria elimination in an area of low transmission with high coverage of malaria control interventions : Protocol for the massiv cluster randomized clinical trial ', JMIR Research Protocols, vol. 9, no. 11, 20904 . https://doi.org/10.2196/20904 JMIR Research Protocols, 9, 11 JMIR Research Protocols, 9(11):20904. JMIR Publications JMIR research protocols, 2020, Vol.9(11), pp.e20904 [Peer Reviewed Journal] JMIR Research Protocols, 9(11):20904. JMIR Publications Inc. JMIR Research Protocols, Vol 9, Iss 11, p e20904 (2020) JMIR research protocols, 9(11):20904. JMIR Publications Inc. JMIR Research Protocols, 9 Dabira, E D, Soumare, H M, Lindsay, S W, Conteh, B, Ceesay, F, Bradley, J, Kositz, C, Broekhuizen, H, Kandeh, B, Fehr, A E, Nieto-Sanchez, C, Muela Ribera, J, Grietens, K P, Smit, M R, Drakeley, C, Bousema, T, Achan, J & D'Alessandro, U 2020, ' Mass drug administration with high-dose ivermectin and dihydroartemisinin-piperaquine for malaria elimination in an area of low transmission with high coverage of malaria control interventions : Protocol for the massiv cluster randomized clinical trial ', JMIR Research Protocols, vol. 9, no. 11, 20904 . https://doi.org/10.2196/20904 |
| ISSN: | 1929-0748 |
| Popis: | BACKGROUND With a decline in malaria burden, innovative interventions and tools are required to reduce malaria transmission further. Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) has been identified as a potential tool to further reduce malaria transmission, where coverage of vector control interventions is already high. However, the impact is limited in time. Combining an ACT with an endectocide treatment that is able to reduce vector survival, such as ivermectin (IVM), could increase the impact of MDA and offer a new tool to reduce malaria transmission. OBJECTIVE The study objective is to evaluate the impact of MDA with IVM plus dihydroartemisinin-piperaquine (DP) on malaria transmission in an area with high coverage of malaria control interventions. METHODS The study is a cluster randomized trial in the Upper River Region of The Gambia and included 32 villages (16 control and 16 intervention). A buffer zone of ~2 km was created around all intervention clusters. MDA with IVM plus DP was implemented in all intervention villages and the buffer zones; control villages received standard malaria interventions according to the Gambian National Malaria Control Program plans. RESULTS The MDA campaigns were carried out from August to October 2018 for the first year and from July to September 2019 for the second year. Statistical analysis will commence once the database is completed, cleaned, and locked. CONCLUSIONS This is the first cluster randomized clinical trial of MDA with IVM plus DP. The results will provide evidence on the impact of MDA with IVM plus DP on malaria transmission. CLINICALTRIAL ClinicalTrials.gov NCT03576313; https://clinicaltrials.gov/ct2/show/NCT03576313 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/20904 |
| Databáze: | OpenAIRE |
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