Population Severance in Manipur at Dopamine Receptor D2 Locus
| Autor: | Mohinder Pal Sachdeva, Achoubi Devi Nongthomban, Rupak Mukhopadhyay, Somibabu Meitei Khangenbam, Benrithung Murry, Sanjenbam Yaiphaba Meitei, Ekata Sinha, Asghar Mohammad, Kiranmala N. Devi, Kallur Nava Saraswathy, Vipin Gupta |
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| Rok vydání: | 2009 |
| Předmět: |
Genetic Markers
Genetics education.field_of_study Polymorphism Genetic Receptors Dopamine D2 Population Haplotype India Locus (genetics) General Medicine Mongoloid Emigration and Immigration Biology Asian People Gene Frequency Haplotypes Anthropology Dopamine receptor D2 Humans Allele education Phylogeny Genetics (clinical) |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 13:831-839 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2009.0047 |
| Popis: | Tibeto-Burman language-speaking Mongoloid groups of northeast India are reported to be genetically highly heterogeneous. Manipur, one of the states of this region sharing a major International border with Myanmar, is also expected to be diversified as seen by its large number of tribal and nontribal groups. A number of genomic markers, that is, autosomal, mitochondrial, and Y chromosomal ones, have been used to understand the peopling of the northeast region.In this article, an attempt is made to understand the peopling of Manipur using three sites (Taq1A, Taq1B, and Taq1D) on the dopamine receptor D2 (DRD2) gene through allele and haplotype frequencies and their distribution patterns.In total, 367 blood samples were collected from eight populations of which three (Meitei, Muslims, and Bamon) are nontribal groups and five (Aimol, Kabui, Paite, Kom, and Thadou) are tribal groups.All the three sites are polymorphic in all the studied populations with relatively lower heterozyosities indicating a genetic discontinuity between the populations of mainland India and northeast India, suggesting the unlikeliness of eastward migration of people from Africa through India.High heterogeneity and predominance of ancestral haplotype (B2D2A1) among the Meitei suggest an admixture of incoming mongoloid groups with an already existing protoastroloid element. The study also highlights the distinctiveness of Manipuri population groups with respect to DRD2 gene polymorphism. |
| Databáze: | OpenAIRE |
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