Effects of vitamin D supplementation on insulin resistance and dyslipidemia in overweight and obese premenopausal women
| Autor: | Narin Nasiroglu Imga, Serdar Güler, Alper Cagri Karci, Dilek Berker, Dilek Öztaş |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
calcitriol
Vitamin obesity medicine.medical_specialty lcsh:Medicine Overweight vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Clinical Research insulin resistance Internal medicine medicine Vitamin D and neurology 030212 general & internal medicine dyslipidemias business.industry lcsh:R General Medicine medicine.disease Obesity Endocrinology chemistry medicine.symptom Metabolic syndrome business Dyslipidemia |
| Zdroj: | Archives of Medical Science, Vol 15, Iss 3, Pp 598-606 (2018) Archives of Medical Science : AMS |
| ISSN: | 1734-1922 |
| DOI: | 10.5114/aoms.2018.75864 |
| Popis: | Introduction Vitamin D deficiency is a common problem, and it is related to increased risk of obesity, metabolic syndrome, atherosclerosis, and cardiovascular disease. Vitamin D has a beneficial effect on dyslipidemia and insulin secretion. We aimed to investigate the impact of vitamin D3 supplementation on anthropometric and laboratory parameters in overweight and obese premenopausal women. Material and methods Seventy-two overweight and 50 obese vitamin-D-deficient premenopausal women (mean age: 43.1 ±10.4 years) were included in the study. Baseline mean 25-hydroxyvitamin D [25(OH)D] level was 6.1 (min.–max. = 2.9–15.8) ng/ml in overweight and was 5.6 (min.–max. = 3.0–22.0) ng/ml in obese subjects. At baseline and at the sixth month of supplementation, serum 25(OH)D, intact parathormone (iPTH), calcium, phosphorus, homeostasis model assessment of insulin resistance (HOMA-IR), and lipid profiles were assessed. Results Following vitamin D3 supplementation in overweight and obese subjects, serum 25(OH)D increased from 6.1 to 34.7 ng/ml and 5.6 to 34.7 ng/ml, respectively (p < 0.001). At the sixth month of supplementation in both overweight and obese subjects, a significant reduction was detected in HOMA-IR (p < 0.001), low-density lipoprotein cholesterol (LDL-C) (p = 0.046, p = 0.044; respectively) and iPTH levels (p ≤ 0.001, p < 0.001; respectively). A negative adjusted correlation was found between changes in 25(OH)D and HOMA-IR (r = –0.581, p < 0.001; r = –0.389, p = 0.005; respectively). A 1 ng/ml increase in serum 25(OH)D level led to a 0.30-fold reduction in HOMA-IR level (p = 0.002). Conclusions Our results support the effect of vitamin D3 supplementation in HOMA-IR and LDL-C improvement in both obese and overweight subjects. Further studies focused on low serum 25(OH)D levels with insulin resistance and dyslipidemia are needed. |
| Databáze: | OpenAIRE |
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