Functional endothelin-1 receptors in rat astrocytoma C6
| Autor: | Fabrice Glibert, Dung Le Nguyen, Odile Durieu-Trautmann, Pierre-Olivier Couraud, A. Donny Strosberg, Philippe Marin |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Inositol Phosphates
Receptors Cell Surface Stimulation Viper Venoms Astrocytoma Biology chemistry.chemical_compound Cyclic AMP Tumor Cells Cultured Extracellular Animals Inositol Receptor Inositol phosphate Aorta Pharmacology chemistry.chemical_classification Receptors Endothelin Endothelins Cell Membrane Colforsin Isoproterenol DNA Neoplasm Endothelin 1 Rats Kinetics chemistry Biochemistry Cell culture Endothelin receptor Thymidine |
| Zdroj: | European Journal of Pharmacology: Molecular Pharmacology. 206:191-198 |
| ISSN: | 0922-4106 |
| Popis: | Rat astrocytoma C6 cells have been recently identified as target cells for ET-1, which stimulates inositol lipid turnover in these cells. It is shown here that binding of ET-1 to high-affinity receptors on C6 cells leads to 40-45% inhibition of isoproterenol-induced intracellular cyclic AMP accumulation, as well as to stimulation of inositol lipid turnover, both effects characterized by an absolute requirement of extracellular calcium. Moreover, ET-1, which has been generally reported to have a mitogenic effect on a variety of target cells including primary rat astrocytes, is shown here to stimulate or, alternatively, inhibit DNA synthesis in C6 cells, depending on the subclone considered. |
| Databáze: | OpenAIRE |
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