The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats
| Autor: | G. Yurtsever, R. Karaali, P.Y. Akyol, Ejder Saylav Bora, Oytun Erbaş |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Medicine (General) Frontal cortex Physiology QH301-705.5 Dura mater Immunology Biophysics Ocean Engineering Pharmacology Electroencephalography Biochemistry Eeg recording Rats Sprague-Dawley R5-920 Sulfasalazine Seizures Behavioral study medicine Animals Animal model General Pharmacology Toxicology and Pharmaceutics Rats Wistar Biology (General) Epilepsy medicine.diagnostic_test business.industry General Neuroscience Cell Biology General Medicine Rats medicine.anatomical_structure Pentylenetetrazole business Emergency service medicine.drug Research Article |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 54, Issue: 12, Article number: e11541, Published: 03 DEC 2021 Brazilian Journal of Medical and Biological Research, Vol 54, Iss 12 (2021) Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research v.54 n.12 2021 Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| Popis: | We aimed to reveal the anti-convulsant effects sulfasalazine and its mechanism in pentylenetetrazole (PTZ)-induced seizures in rats. Forty-eight male Wistar albino rats (200-250 g) were randomly divided into two groups: 24 for electroencephalography (EEG) recording (group A) and 24 for behavioral studies (group B). About 70 mg/kg PTZ was used for behavioral studies after sulfasalazine administration and 35 mg/kg PTZ was used for EEG recording after sulfasalazine administration. Electrodes were implanted on the dura mater over the left frontal cortex and the reference electrode was implanted over the cerebellum for EEG recording. Racine’s convulsion scale, first myoclonic jerk onset time, spike percentages, brain malondialdehyde (MDA), superoxide dismutase (SOD), and prostaglandin F2α (PGF2α) levels were evaluated between the groups. First myoclonic jerk onset time was significantly shorter in the saline group than both 250 and 500 mg/kg sulfasalazine groups (P |
| Databáze: | OpenAIRE |
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