Patients with bipolar disorder show differential executive dysfunctions: A case-control study
| Autor: | Raymond C.K. Chan, Zhi Li, Meranda M.W. Leung, Chi F. Tsui, Angie C.W. Au, Simon S.Y. Lui, Hera K.H. Yeung, Tian-xiao Yang, Eric F.C. Cheung, Ya Wang, Chi Wai Cheng |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Bipolar Disorder Bipolar I disorder medicine.medical_treatment Neuropsychological Tests Executive Function 03 medical and health sciences 0302 clinical medicine Visual memory Memory medicine Humans Attention Cognitive Dysfunction Bipolar disorder Supervisory attentional system Biological Psychiatry Rehabilitation Case-control study Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Case-Control Studies Neurocognitive Tests Female Disease characteristics Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Psychiatry Research. 238:129-136 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2016.01.055 |
| Popis: | Executive deficits in euthymic bipolar I disorder were examined in a fractionated manner based on the "Supervisory Attentional System" (SAS) model, and the relationship between the degree of executive impairment and the demographic and clinical characteristics of bipolar I participants was explored. A battery of neurocognitive tests capturing specific components of executive function was administered on 30 patients with bipolar I disorder in euthymic state, and compared with 30 healthy controls who were matched by age, gender and IQ. A differential impairment in executive function was demonstrated in euthymic bipolar I participants by using a fractionated approach of the SAS. Euthymic bipolar I patients were found to have significantly poorer performance in immediate and delayed visual memory; and in the executive domains of "initiation", "sustained attention", and "attention allocation and planning". Those with a greater number of executive impairments had lower IQ and higher negative sub-scores on PANSS. These findings might provide a the basis for further studies on identifying the executive components that are associated with particular disease characteristics of bipolar disorder, and those with poorer functional outcome, so that rehabilitation can be focused on the selective domains concerned. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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