Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms
| Autor: | Elizabeth M. Angus, Connor J Frapwell, Paul Skipp, Yanmin Hu, Robert P. Howlin, Raymond N. Allan, Jeremy S. Webb, Anthony R.M. Coates |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
medicine.drug_class Antibiotics Microbial Sensitivity Tests medicine.disease_cause antibiotics Microbiology Cell wall 03 medical and health sciences chemistry.chemical_compound proteomics Vancomycin medicine Humans Pharmacology (medical) 030304 developmental biology Pharmacology 0303 health sciences HT61 030306 microbiology Biofilm Quinoline Staphylococcal Infections biochemical phenomena metabolism and nutrition Antimicrobial Anti-Bacterial Agents Infectious Diseases chemistry Susceptibility Biofilms Quinolines Staphylococcus |
| Zdroj: | Antimicrobial Agents and Chemotherapy |
| ISSN: | 1098-6596 |
| Popis: | Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections. |
| Databáze: | OpenAIRE |
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