Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis

Autor: Danielle Fontana Pereira, Virgínia Demarchi Kappel, Samantha Manes Guesser, Carlos Henrique Blum da Silva, Eloir Paulo Schenkel, Fátima Regina Mena Barreto Silva, Flávio Henrique Reginatto, Luisa Helena Cazarolli
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Blood Glucose
Glycation End Products
Advanced
Male
disaccharidase
Glycosylation
Time Factors
medicine.medical_treatment
Pharmaceutical Science
Analytical Chemistry
boats
chemistry.chemical_compound
Glycation
Insulin Secretion
Drug Discovery
Articulata
Homeostasis
Glucose homeostasis
Glycated Serum Albumin
Baccharis articulata
diabetes
biology
Glycogen
Baccharis
Chemistry
Chemistry (miscellaneous)
Molecular Medicine
medicine.drug
insulin
medicine.medical_specialty
Article
Diabetes Mellitus
Experimental
Time
1-Butanol
Phenols
boats.ship_class
Internal medicine
medicine
Animals
Hypoglycemic Agents
Glycoside Hydrolase Inhibitors
Rats
Wistar
Physical and Theoretical Chemistry
Serum Albumin
Flavonoids
Plant Extracts
Insulin
glycation
Organic Chemistry
Albumin
Glucose Tolerance Test
biology.organism_classification
Rats
Glucose
Endocrinology
Glipizide
Zdroj: Molecules; Volume 17; Issue 6; Pages: 6754-6768
Molecules
ISSN: 1420-3049
DOI: 10.3390/molecules17066754
Popis: In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties.
Databáze: OpenAIRE
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