Quantitative Susceptibility Mapping for Following Intracranial Hemorrhage
| Autor: | Laura C. Gioia, Hongfu Sun, Mahesh Kate, Derek Emery, Kenneth Butcher, Ana C Klahr, Alan H. Wilman |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Intraclass correlation Interobserver reproducibility Inversion recovery Phase image 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Image Processing Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies cardiovascular diseases Prospective cohort study Aged Aged 80 and over Observer Variation Brain Mapping business.industry Brain Reproducibility of Results Quantitative susceptibility mapping Middle Aged Magnetic Resonance Imaging nervous system diseases Iron content Female Tomography Tomography X-Ray Computed business Nuclear medicine Intracranial Hemorrhages 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Radiology. 288:830-839 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2018171918 |
| Popis: | Purpose To follow the evolution of intracranial hemorrhage (ICH) by using quantitative susceptibility mapping (QSM). Materials and Methods Thirty-six patients with ICH confirmed at CT were enrolled to follow ICH evolution on day 2, 7, and 30 after symptom onset between August 2013 and April 2017. QSM was reconstructed from MRI gradient-echo phase images acquired at 1.5 T or 3.0 T. ICH regions were manually drawn on two-dimensional sections of co-registered CT and MR images independently by two raters. The ICH areas and mean values were compared between CT and MRI by using Bland-Altman plots and Pearson correlation. QSM time evolution of ICH was assessed by using paired t tests and was compared with conventional T2-weighted fluid-attenuated inversion recovery, or T1-weighted or T2*-weighted magnitude intensities. Results Significant reductions in ICH susceptibility were found between day 2 and day 7 (P < .001) and between day 7 and day 30 (P = .003), corresponding to different disease stages. The ICH areas measured at CT and QSM were linearly correlated (r2 = 0.98). The mean CT attenuation and mean susceptibility of ICH were linearly correlated (r2 = 0.29). Excellent intra- and interobserver reproducibility were found for QSM (intraclass correlation coefficient, 0.987 and 0.966, respectively). Conclusion Longitudinal evolution of intracranial hemorrhage (ICH) by using quantitative susceptibility mapping (QSM) demonstrated susceptibility differences in different disease stages, which was not found at conventional MRI; therefore, QSM may assist in quantitatively following ICH iron content. |
| Databáze: | OpenAIRE |
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