Is arterial wall-strain stiffening an additional process responsible for atherosclerosis in coronary bifurcations?: an in vivo study based on dynamic CT and MRI
| Autor: | Roderic I. Pettigrew, Jacques Ohayon, M. Malvè, Miguel Ángel Martínez, Philippe Tracqui, Saami K. Yazdani, Gérard Finet, Julie Heroux, A. García, Manuel Doblaré, Ahmed M. Gharib |
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| Přispěvatelé: | dyctim, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Conselleria Agricultura Pesca y Alimentacion, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Department of Hemodynamics and Interventional Cardiology, Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
MESH: Models Cardiovascular Contraction (grammar) Time Factors Physiology MESH: Myocardial Contraction [SDV]Life Sciences [q-bio] Hemodynamics 02 engineering and technology Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography MESH: Magnetic Resonance Imaging Coronary artery disease 0302 clinical medicine Integrative Cardiovascular Physiology and Pathophysiology Medicine MESH: Coronary Vessels MESH: Coronary Artery Disease MESH: Biomechanics MESH: Aged MESH: Middle Aged MESH: Stress Mechanical medicine.diagnostic_test MESH: Finite Element Analysis Biomechanics Models Cardiovascular Middle Aged Coronary Vessels Magnetic Resonance Imaging Arterial tree Plaque Atherosclerotic MESH: Predictive Value of Tests Biomechanical Phenomena MESH: Nonlinear Dynamics medicine.anatomical_structure Cardiology Female Cardiology and Cardiovascular Medicine MESH: Tomography X-Ray Computed Artery Adult medicine.medical_specialty MESH: Hemodynamics 0206 medical engineering Finite Element Analysis 03 medical and health sciences Predictive Value of Tests Physiology (medical) Internal medicine Image Interpretation Computer-Assisted Humans MESH: Plaque Atherosclerotic Aged MESH: Humans business.industry MESH: Time Factors Magnetic resonance imaging MESH: Adult medicine.disease 020601 biomedical engineering Myocardial Contraction Elasticity MESH: Male MESH: Coronary Angiography Coronary arteries Nonlinear Dynamics MESH: Elasticity Stress Mechanical business Tomography X-Ray Computed MESH: Image Interpretation Computer-Assisted MESH: Female |
| Zdroj: | AJP-Heart and Circulatory Physiology AJP-Heart and Circulatory Physiology, American Physiological Society, 2011, 301 (3), pp.H1097-106. ⟨10.1152/ajpheart.01120.2010⟩ |
| ISSN: | 0363-6135 1522-1539 |
| DOI: | 10.1152/ajpheart.01120.2010⟩ |
| Popis: | Coronary bifurcations represent specific regions of the arterial tree that are susceptible to atherosclerotic lesions. While the effects of vessel compliance, curvature, pulsatile blood flow, and cardiac motion on coronary endothelial shear stress have been widely explored, the effects of myocardial contraction on arterial wall stress/strain (WS/S) and vessel stiffness distributions remain unclear. Local increase of vessel stiffness resulting from wall-strain stiffening phenomenon (a local process due to the nonlinear mechanical properties of the arterial wall) may be critical in the development of atherosclerotic lesions. Therefore, the aim of this study was to quantify WS/S and stiffness in coronary bifurcations and to investigate correlations with plaque sites. Anatomic coronary geometry and cardiac motion were generated based on both computed tomography and MRI examinations of eight patients with minimal coronary disease. Computational structural analyses using the finite element method were subsequently performed, and spatial luminal arterial wall stretch (LWStretch) and stiffness (LWStiff) distributions in the left main coronary bifurcations were calculated. Our results show that all plaque sites were concomitantly subject to high LWStretch and high LWStiff, with mean amplitudes of 34.7 ± 1.6% and 442.4 ± 113.0 kPa, respectively. The mean LWStiff amplitude was found slightly greater at the plaque sites on the left main coronary artery (mean value: 482.2 ± 88.1 kPa) compared with those computed on the left anterior descending and left circumflex coronary arteries (416.3 ± 61.5 and 428.7 ± 181.8 kPa, respectively). These findings suggest that local wall stiffness plays a role in the initiation of atherosclerotic lesions. |
| Databáze: | OpenAIRE |
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