Outcome of Oral and Intra-arterial Nimodipine Administration After Aneurysmal Subarachnoid Haemorrhage – A Single-centre Study
| Autor: | Thomas Kirschning, Aldemar Andres Hegewald, Holger Wenz, Eva Neumaier-Probst, Marcel Seiz-Rosenhagen, Gregory Ehrlich |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research Subarachnoid hemorrhage Vasodilator Agents medicine.medical_treatment Administration Oral General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine Intra arterial Humans Infusions Intra-Arterial Nimodipine Aged Aged 80 and over Pharmacology Endovascular coiling business.industry Incidence Incidence (epidemiology) Hemodynamics Intracranial Aneurysm Vasospasm Middle Aged Subarachnoid Hemorrhage medicine.disease Stroke Treatment Outcome Injections Intra-Arterial 030220 oncology & carcinogenesis Anesthesia Cohort Female Subarachnoid haemorrhage business Research Article medicine.drug |
| Zdroj: | In Vivo. 33:1967-1975 |
| ISSN: | 1791-7549 0258-851X |
| DOI: | 10.21873/invivo.11692 |
| Popis: | Background Oral nimodipine is administered to improve clinical outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). In this study, clinical outcome in patients with and without oral nimodipine administration was assessed. Materials and methods A total of 105 patients did not receive oral nimodipine but did receive intra-arterial nimodipine in the occurrence of hemodynamically relevant vasospasm after aSAH, whereas 74 patients received applications of both. Demographic/radiological details and clinical presentation were abstracted from the case records. Results Patient baseline characteristics were comparable, a predominance of endovascular coiling was shown in cohort 2 (p=0.0135). Severity of initial aSAH and clinical status at admission (Hunt and Hess) was significantly higher in those receiving oral nimodipine. Incidence of angiographic vasospasm was significantly higher in patients not treated with oral nimodipine (p=0.0305); a significantly better outcome measured by the National Institute of Health Stroke Scale (p=0.0213), was noted in those receiving oral nimodipine. Conclusion Oral nimodipine administration improved clinical outcome of patients after aSAH and should be administered routinely for such patients. |
| Databáze: | OpenAIRE |
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