Comorbidity and quality of life in childhood cancer survivors treated with proton beam therapy
| Autor: | Yoshiko Oshiro, Ryoko Suzuki, Kyoko Hidaka, Atsushi Iwabuchi, Kouji Masumoto, Ai Muroi, Ryo Sumazaki, Hiroko Fukushima, Toko Shinkai, Takashi Yamamoto, Tomohei Nakao, Hideyuki Sakurai, Masashi Mizumoto, Takashi Fukushima |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Childhood cancer Comorbidity 03 medical and health sciences 0302 clinical medicine Cancer Survivors Japan Quality of life Clinical information Proton Therapy medicine Humans Multimodal treatment 030212 general & internal medicine Child Adverse effect Head and neck Brain Neoplasms business.industry Medical record Infant Newborn Infant medicine.disease humanities Head and Neck Neoplasms Child Preschool 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Quality of Life Female business Follow-Up Studies |
| Zdroj: | Pediatrics International. 59:1039-1045 |
| ISSN: | 1328-8067 |
| DOI: | 10.1111/ped.13323 |
| Popis: | The rate of childhood cancer survival has recently reached80%. Various adverse events among childhood cancer survivors (CCS) have been reported. Proton beams are able to avoid unnecessary irradiation to normal/vital organs. We conducted a quality of life (QOL) study for CCS who were treated with proton beam therapy (PBT).We included those patients treated with PBT to the brain, head, or neck and who were ≤15 years old at the University of Tsukuba Hospital between 1983 and 2011. Clinical information was collected from medical records. Questionnaires including the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales (which assess health-related quality of life) were sent to the families/patients.Sixty patients were included. Median age at treatment was 6.2 years. The number of patients with status alive/dead/unknown was 32/24/4. Median follow-up period was 63.0 months (range, 48-340 months) for survivors. Questionnaires were sent to 25 families/patients and 19 were returned. PedsQL was assessed for 17 patients. Eleven of 32 living patients had at least one comorbidity grade 3/4. Average QOL score was above that for Japanese schoolchildren and adolescents. There was no correlation with comorbidity, and only longer time from treatment was correlated with a higher PedsQL score (P = 0.006).CCS who were treated with multimodal treatment using PBT had a higher QOL score. Higher score was related to longer time since treatment, regardless of comorbidity. |
| Databáze: | OpenAIRE |
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