Formyl Peptide Receptor (FPR)1 Modulation by Resveratrol in an LPS-Induced Neuroinflammatory Animal Model
| Autor: | Giuseppe Nicolardi, Chiara Porro, Piergianni Moda, Laura Giannotti, Rosa Calvello, Dario Domenico Lofrumento, Maria Antonietta Panaro, Francesco De Nuccio, Antonia Cianciulli |
|---|---|
| Přispěvatelé: | Calvello, Rosa, Cianciulli, Antonia, Porro, Chiara, Moda, Piergianni, DE NUCCIO, Francesco, Nicolardi, Giuseppe, Giannotti, Laura, Antonietta Panaro, Maria, Lofrumento, Dario Domenico |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharides
Male 0301 basic medicine Anti-Inflammatory Agents microglia Pharmacology Resveratrol resveratrol Models Biological Article Proinflammatory cytokine neuroinflammation Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sirtuin 1 Downregulation and upregulation Glial Fibrillary Acidic Protein Animals TX341-641 RNA Messenger Receptor Neuroinflammation Inflammation Nutrition and Dietetics Formyl peptide receptor biology Nutrition. Foods and food supply Tumor Necrosis Factor-alpha Chemistry Calcium-Binding Proteins Microfilament Proteins food and beverages Receptors Formyl Peptide FPR neuroinflammation neurodegeneration Disease Models Animal Interleukin 1 Receptor Antagonist Protein 030104 developmental biology nutrition Astrocytes biology.protein Protein deacetylase Inflammation Mediators FPR 030217 neurology & neurosurgery Signal Transduction Food Science |
| Zdroj: | Nutrients Volume 13 Issue 5 Nutrients, Vol 13, Iss 1418, p 1418 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13051418 |
| Popis: | Among therapeutic approaches that have been investigated, targeting of receptors implicated in managing neuroinflammation has been described. One such family of receptors comprises the formyl peptide receptors (FPRs) whose ligands could play a role in host defense. The murine FPR gene family includes at least six members while in humans there are only three. The two most important members are the Fpr1 and Fpr2. Fpr1encodes murine FPR1, which is considered the murine orthologue of human FPR. Resveratrol, a non-flavonoid polyphenol rich in red wine and grapes, apart from its beneficial health effects and anti-inflammatory properties, has been reported to reduce neuroinflammation in different neurodegenerative disease models. Resveratrol anti-inflammatory responses involve the activation of the protein deacetylase sirtuin 1 (SIRT1) gene. In this work we have investigated in an LPS-based murine model of neuroinflammation the role of FPR1, examining not only if this receptor undergoes a reduction of its expression during neuroinflammation, but also whether treatment with resveratrol was able to modulate its expression leading to an amelioration of neuroinflammatory picture in a murine model of neuroinflammation. Results of this work showed that FPR1 together with SIRT1 resulted upregulated by resveratrol treatment and that this increase is associated with an amelioration of the neuroinflammatory picture, as demonstrated by the induction of IL-10 and IL1-RA expression and the downregulation of proinflammatory mediators, such as TNF-α and IL-1β. The expression and the modulation of FPR1 by resveratrol may be evaluated in order to propose a novel anti-inflammatory and pro-resolving therapeutic approach for the reduction of the detrimental effects associated with neuro-inflammation based neurodegenerative diseases and also as a promising strategy to promote human health by a diet rich in antioxidative bioactive compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|