Invasion and translocation of uropathogenic Escherichia coli isolated from urosepsis and patients with community-acquired urinary tract infection
| Autor: | Anna Kuballa, Mohammad Katouli, N Masters, Bahareh Owrangi, Tara L. Vollmerhausen, Christian O'Dea |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Virulence Factors Urinary system 030106 microbiology Virulence Chromosomal translocation Biology urologic and male genital diseases medicine.disease_cause Bacterial Adhesion Cell Line Microbiology Sepsis 03 medical and health sciences Medical microbiology Antigen medicine Humans Uropathogenic Escherichia coli Escherichia coli Escherichia coli Infections Aged Aged 80 and over Escherichia coli Proteins General Medicine Middle Aged bacterial infections and mycoses medicine.disease Bacterial Load female genital diseases and pregnancy complications Gut Epithelium Community-Acquired Infections 030104 developmental biology Infectious Diseases Protein Biosynthesis Urinary Tract Infections Female |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 37:833-839 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-017-3176-4 |
| Popis: | Uropathogenic Escherichia coli (UPEC) strains are found in high numbers in the gut of patients with urinary tract infections (UTIs). We hypothesised that in hospitalised patients, UPEC strains might translocate from the gut to the blood stream and that this could be due to the presence of virulence genes (VGs) that are not commonly found in UPEC strains that cause UTI only. To test this, E. coli strains representing 75 dominant clonal groups of UPEC isolated from the blood of hospitalised patients with UTI (urosepsis) (n = 22), hospital-acquired (HA) UTI without blood infection (n = 24) and strains isolated from patients with community-acquired (CA)-UTIs (n = 29) were tested for their adhesion to, invasion and translocation through Caco-2 cells, in addition to the presence of 34 VGs associated with UPEC. Although there were no differences in the rate and degree of translocation among the groups, urosepsis and HA-UTI strains showed significantly higher abilities to adhere (P = 0.0095 and P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink