The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans

Autor:	Haoyi Fu, Nicola L. Hawley, Jenna C. Carlson, Emily M. Russell, Alysa Pomer, Hong Cheng, Take Naseri, Muagututi‘a Sefuiva Reupena, Ranjan Deka, Courtney C. Choy, Stephen T. McGarvey, Ryan L. Minster, Daniel E. Weeks
Rok vydání:	2022
Předmět:	Adult Cohort Studies Male Nutrition and Dietetics Genotype Endocrinology Diabetes and Metabolism Humans Female Obesity Alleles Aged Body Mass Index
Zdroj:	Obesity Research & Clinical Practice. 16:220-227
ISSN:	1871-403X
DOI:	10.1016/j.orcp.2022.04.004
Popis:	A missense variant, rs373863828, in CREBRF is associated with obesity in Polynesians. We investigate whether rs373863828 and other factors are associated with body mass index (BMI) rate-of-change between 2010 and 2017-19 in Samoans.We used sex-stratified models to test whether BMI rate-of-change was associated with rs373863828, baseline BMI, age, residence, physical activity, and household asset score in a cohort study of 480 Samoan adults measured in both 2010 (mean age 43.8 years) and 2017-19.Mean BMI increased from 32.1 to 33.5 kg/mIn Samoans, the minor A allele of rs373863828 is associated with an increased rate-of-change in BMI in females. On average, BMI of females with the AA genotype increased 0.30 kg/m
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ee21b140fc3cceeed2f9ef44042ee6 https://doi.org/10.1016/j.orcp.2022.04.004 Zobrazit plný text záznamu Full Text from ScienceDirect