Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients

Autor: Roberta Pang, Ronnie Tung-Ping Poon, Lui Ng, Virginia H. T. Kwan, Wai Lun Law, Ariel Chow, Thomas Yau
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Cancer Research
RHOA
RhoC
Metastasis
Random Allocation
0302 clinical medicine
Surgical oncology
Medicine
Neoplasm Metastasis
Aged
80 and over
biology
Liver Neoplasms
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Oncology
rhoC GTP-Binding Protein
030220 oncology & carcinogenesis
Hepatocellular carcinoma
PIN1
Disease Progression
Female
Research Article
Adult
Carcinoma
Hepatocellular
Adolescent
lcsh:RC254-282
Disease-Free Survival
03 medical and health sciences
Young Adult
Pin1
Recurrence free survival
Genetics
Humans
RNA
Messenger
Aged
Neoplasm Staging
Postoperative Care
business.industry
RhoA
medicine.disease
Rho signaling
digestive system diseases
NIMA-Interacting Peptidylprolyl Isomerase
030104 developmental biology
Cancer research
biology.protein
Neoplasm Recurrence
Local
business
rhoA GTP-Binding Protein
Zdroj: BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
ISSN: 1471-2407
Popis: Background Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC progression and metastasis. In the current study, we investigated the clinical correlation between Pin1, RhoA and RhoC and their association with HCC metastasis. Methods Using a randomized study design of primary HCC samples from 139 patients, we determined messenger RNA expression of Pin1, RhoA and RhoC and their prognostic value. Results Our findings demonstrated for the first time the clinical correlation of Pin1 in HCC metastasis. Pin1, RhoA and RhoC transcript levels were significantly higher in HCC specimens when compared with the paired adjacent non-tumorous liver. Pin1 overexpression was closely correlated with that of RhoA (R = 0.562, p
Databáze: OpenAIRE
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