An olfactory receptor for food-derived odours promotes male courtship in Drosophila
| Autor: | Richard Benton, Yael Grosjean, Jérôme Cortot, Jean-Pierre Farine, Liliane Abuin, Raphael Rytz, Gregory S.X.E. Jefferis |
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| Přispěvatelé: | Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Université de Lausanne ( UNIL ), MRC, Mol Biol Lab, Div Neurobiol, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Université de Lausanne (UNIL) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Oviposition [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition MESH : Genotype MESH : Oviposition Courtship MESH: Genotype Sexual Behavior Animal 0302 clinical medicine MESH : Drosophila melanogaster MESH: Animals MESH : Female Mating Sex Attractants MESH: Sexual Behavior Animal MESH: Oviposition media_common Phenylacetates 0303 health sciences education.field_of_study Multidisciplinary MESH: Receptors Ionotropic Glutamate MESH : Receptors Ionotropic Glutamate Anatomy MESH: Acetaldehyde MESH : Odors Cell biology medicine.anatomical_structure Drosophila melanogaster MESH: Sex Attractants Sex pheromone behavior and behavior mechanisms Pheromone fruitless Female MESH : Food MESH: Fruit MESH: Food Genotype media_common.quotation_subject MESH : Male Population MESH: Courtship MESH : Acetaldehyde Acetaldehyde MESH : Fruit Biology Receptors Ionotropic Glutamate Olfactory Receptor Neurons MESH: Drosophila melanogaster 03 medical and health sciences medicine Animals education MESH : Sexual Behavior Animal 030304 developmental biology MESH : Sex Attractants Olfactory receptor MESH: Odors MESH: Phenylacetates MESH : Courtship fungi MESH : Phenylacetates MESH: Olfactory Receptor Neurons biology.organism_classification MESH: Male Food Fruit Odorants MESH : Olfactory Receptor Neurons MESH : Animals MESH: Female [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition 030217 neurology & neurosurgery |
| Zdroj: | Nature Nature, Nature Publishing Group, 2011, 478 (7368), pp.236-40. 〈10.1038/nature10428〉 Nature, Nature Publishing Group, 2011, 478 (7368), pp.236-40. ⟨10.1038/nature10428⟩ |
| ISSN: | 0028-0836 1476-4679 |
| DOI: | 10.1038/nature10428〉 |
| Popis: | International audience; Many animals attract mating partners through the release of volatile sex pheromones, which can convey information on the species, gender and receptivity of the sender to induce innate courtship and mating behaviours by the receiver. Male Drosophila melanogaster fruitflies display stereotyped reproductive behaviours towards females, and these behaviours are controlled by the neural circuitry expressing male-specific isoforms of the transcription factor Fruitless (FRU(M)). However, the volatile pheromone ligands, receptors and olfactory sensory neurons (OSNs) that promote male courtship have not been identified in this important model organism. Here we describe a novel courtship function of Ionotropic receptor 84a (IR84a), which is a member of the chemosensory ionotropic glutamate receptor family, in a previously uncharacterized population of FRU(M)-positive OSNs. IR84a-expressing neurons are activated not by fly-derived chemicals but by the aromatic odours phenylacetic acid and phenylacetaldehyde, which are widely found in fruit and other plant tissues that serve as food sources and oviposition sites for drosophilid flies. Mutation of Ir84a abolishes both odour-evoked and spontaneous electrophysiological activity in these neurons and markedly reduces male courtship behaviour. Conversely, male courtship is increased--in an IR84a-dependent manner--in the presence of phenylacetic acid but not in the presence of another fruit odour that does not activate IR84a. Interneurons downstream of IR84a-expressing OSNs innervate a pheromone-processing centre in the brain. Whereas IR84a orthologues and phenylacetic-acid-responsive neurons are present in diverse drosophilid species, IR84a is absent from insects that rely on long-range sex pheromones. Our results suggest a model in which IR84a couples food presence to the activation of the fru(M) courtship circuitry in fruitflies. These findings reveal an unusual but effective evolutionary solution to coordinate feeding and oviposition site selection with reproductive behaviours through a specific sensory pathway. |
| Databáze: | OpenAIRE |
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