Pediatric Survivors of Retinoblastoma Are at Risk for Altered Bone Metabolism After Chemotherapy Treatment Early in Life
| Autor: | Petra Temming, Eva Biewald, Berthold P. Hauffa, Michael M. Schündeln, Jens Bauer, Wolfgang Sauerwein, Pia K Hauffa, Corinna Grasemann, Norbert Bornfeld |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Cyclophosphamide Pediatric endocrinology medicine.medical_treatment Medizin vitamin D deficiency Carboplatin Bone remodeling Fractures Bone Risk Factors Antineoplastic Combined Chemotherapy Protocols medicine Humans Survivors Bone pain Etoposide Chemotherapy Retinoblastoma business.industry Hematology Vitamin D Deficiency medicine.disease Surgery Oncology Vincristine Child Preschool Pediatrics Perinatology and Child Health Female Thyroid function medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | Pediatric Hematology and Oncology. 32:455-466 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.3109/08880018.2015.1048912 |
| Popis: | Survivors of childhood cancer frequently suffer from endocrine late effects, which are, at least partly, attributed to toxic effects of chemotherapy. Treatment of retinoblastoma typically involves chemotherapy at a very young age. The authors conducted a cross-sectional study to assess bone health in a pediatric cohort of 33 survivors of retinoblastoma (mean age: 4.4 years) who had undergone chemotherapy treatment at an especially young age (mean age: 0.76 years). Of these patients, 14 had unilateral and 19 bilateral retinoblastoma. Polychemotherapy consisted of treatment with cyclophosphamide, etoposide, vincristine, and carboplatin. Ten patients had undergone external beam radiotherapy. Clinical and biochemical parameters of growth, pubertal development, and bone health were obtained. A vitamin D deficiency was found in 51.7% of the patients, and 13.7% of patients displayed severe vitamin D deficiency. Secondary hyperparathyroidism and altered readings for bone formation or resorption markers were present in 15%. Nine percent reported bone pain or experienced fractures of the long bones after primary diagnosis. No difference between children with bilateral and unilateral disease or irradiated versus nonirradiated children was observed. The parameters of thyroid function, growth, and pubertal development were within age-appropriate norms in almost all children. In conclusion, altered parameters of bone health can be present in survivors of retinoblastoma at a young age and warrant regular follow-up in these children. The endocrine hypothalamic-pituitary axes, however, were not impaired at this early age in this group of survivors of retinoblastoma. |
| Databáze: | OpenAIRE |
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