Endoplasmic Reticulum Stress Markers in SARS-COV-2 Infection and Pneumonia: Case-Control Study
| Autor: | Özgür Kurt, Aylin Köseler, Tarik Goren, Ibrahim Turkcuer, Ramazan Sabirli |
|---|---|
| Přispěvatelé: | Acibadem University Dspace |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research Glucose-regulated protein Disease CHOP virus pneumonia Gastroenterology eIF-2 Kinase 0302 clinical medicine skin and connective tissue diseases Endoplasmic Reticulum Chaperone BiP Heat-Shock Proteins clinical article biology protein kinase biological marker Endoplasmic Reticulum Stress unclassified drug glucose regulated protein 78 030220 oncology & carcinogenesis endoplasmic reticulum stress Female Coronavirus Infections Research Article GRP78 medicine.medical_specialty Pneumonia Viral Enzyme-Linked Immunosorbent Assay SARS-COV-2 General Biochemistry Genetics and Molecular Biology Article enzyme blood level 03 medical and health sciences coronavirus disease 2019 Internal medicine medicine Humans controlled study human Pandemics Pharmacology business.industry Endoplasmic reticulum fungi Case-control study COVID-19 Emergency department growth arrest and DNA damage inducible protein 153 Pneumonia medicine.disease enzyme linked immunosorbent assay respiratory tract diseases body regions protein blood level Case-Control Studies protein kinase RNA like endoplasmic reticulum kinase biology.protein Unfolded protein response business Biomarkers Transcription Factor CHOP |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 |
| Popis: | Background/Aim: A novel human coronavirus, named SARS-COV-2, has recently caused thousands of deaths all around the world. Endoplasmic reticulum (ER) stress plays an important role in the development of diseases. Patients and Methods: We aimed to to investigate the relationship between ER stress markers in patients infected with SARS-COV-2 and patients with pneumonia. A total of 9 patients (4 patients diagnosed with pneumonia and 5 patients diagnosed with SARS-COV-2 infection) who admitted to the emergency Department with symptoms of pneumonia and SARS-COV-2 were included in the study. A total of 18 healthy individuals without any known chronic or acute disease and drug use were included as the healthy control group. Serum human glucose regulated protein 78 (GRP78), serum human C/EBP homologous protein (CHOP) and serum human phospho extracellular signal regulated kinase (PERK) levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: GRP78 levels were found to be significantly higher in SARS-COV-2 positive cases compared to individuals in other groups. Serum GRP- 78 level median value was statistically significantly higher in SARS-COV-2-positive group compared to the other groups (p=0.0003). Serum PERK level was statistically significantly higher in SARS-COV-2-positive pneumonia cases (p=0.046). Conclusion: An association was shown between GRP78 and SARS-COV-2 infection. Although a small number of patients was investigated, these results will be important and guide future treatments of SARS-COV-2. © 2020 International Institute of Anticancer Research. All rights reserved. |
| Databáze: | OpenAIRE |
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