Effect of Intra Uterine Granulocyte Colony Stimulating Factor vs. Human Chorionic Gonadotropin at Ovum Pick Up Day on Pregnancy Rate in IVF/ICSI Cases With Recurrent Implantation Failure
| Autor: | Ahmed Hussein, Osama Mohamed Deif, Ahmed Eldemery, Haitham Torky, Heba Marie, Ashraf Abo-Louz, Atef Shata, El-Sayed El-Desouky, Rania Aly, Ashraf El-Baz, Osama S. El-Taher |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pregnancy Rate medicine.medical_treatment Fertilization in Vitro Placebo Chorionic Gonadotropin Human chorionic gonadotropin law.invention Miscarriage Implantation failure Randomized controlled trial Pregnancy law Granulocyte Colony-Stimulating Factor Humans Medicine Prospective Studies Sperm Injections Intracytoplasmic Saline business.industry Obstetrics Obstetrics and Gynecology Embryo Transfer medicine.disease Granulocyte colony-stimulating factor Abortion Spontaneous Pregnancy rate Female Saline Solution business |
| Zdroj: | JBRA Assisted Reproduction. |
| ISSN: | 1518-0557 |
| DOI: | 10.5935/1518-0557.20210056 |
| Popis: | Objective Recurrent implantation failure is defined as failure to achieve clinical pregnancy after the transfer of four or more good-quality embryos in a minimum of three fresh or frozen cycles in a woman aged less than 40 years. The objective is to compare between the effect of intrauterine G-CSF, hCG, and saline solution injection (as placebo) at the day of ovum pick-up on clinical pregnancy, chemical pregnancy, implantation, and miscarriage rates in patients with recurrent implantation failure undergoing IVF/ICSI. Methods This prospective, double blind, parallel, randomized controlled trial included 150 patients equally divided into 3 groups, each containing 50 individuals. Subjects in Group 1 received intrauterine injections of G-CSF; Group 2: received intrauterine injections of 500 IU of hCG; and Group 3 received intrauterine injections of saline solution as placebo. The primary outcome measure is clinical pregnancy rate. Secondary outcomes are biochemical pregnancy, implantation, and miscarriage rates. Results Clinical pregnancy, biochemical pregnancy, and implantation rates were highest in the group given G-CSF and lowest in the group administered saline solution; miscarriage rates were not significantly different between the groups. Conclusions Intrauterine administration of G-CSF at a dose of 100 µg/1.0 cc at the time of ovum pick-up is associated with better clinical pregnancy, chemical pregnancy, and implantation rates as compared with intrauterine saline solution administration. Further studies are needed to determine the optimum timing of intrauterine administration of G-CSF that achieves the best results, and longer follow-up is needed to determine take-home baby percentages. |
| Databáze: | OpenAIRE |
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