Basal Ganglia Output Controls Active Avoidance Behavior
| Autor: | Manuel A. Castro-Alamancos, Germán Vega-Flores, Sebastian Hormigo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Proteomics 0301 basic medicine Mice Transgenic Optogenetics Avoidance response Basal Ganglia Developmental psychology Mice 03 medical and health sciences 0302 clinical medicine Neural Pathways Pars Reticulata Basal ganglia Avoidance Learning medicine Animals Neurons Phobias General Neuroscience Social anxiety Classical conditioning Articles Fear Chemogenetics medicine.disease Electrophysiological Phenomena 030104 developmental biology nervous system Anxiety medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Neuroscience. 36:10274-10284 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.1842-16.2016 |
| Popis: | Engrained avoidance behavior is highly adaptive when it keeps away harmful events and can be highly maladaptive when individuals elude harmless situations in anxiety disorders, but the neural circuits that mediate avoidance are poorly understood. Using DREADDs and optogenetics in mice, we show that the output of the basal ganglia through the substantia nigrapars reticulata(SNr) controls active avoidance. SNr excitation blocks avoidance to a conditioned sensory stimulus while preserving the ability to escape the harmful event. Conversely, SNr inhibition facilitates avoidance to the conditioned stimulus and suffices to drive avoidance without any conditioned sensory stimulus. The results highlight a midbrain circuit that gates avoidance responses, which can be targeted to ameliorate maladaptive avoidance in psychiatric disorders.SIGNIFICANCE STATEMENTIn many circumstances, subjects respond to fearful situations with avoidance. This is a useful coping strategy in situations in which there is impending danger. However, avoidance responses can also be maladaptive, as in anxiety disorders such as phobias (e.g., avoiding air transportation) and social anxiety (e.g., avoiding social situations). Despite the obvious clinical relevance, little is known about the neural circuits that mediate active avoidance. Using chemogenetics and optogenetics, we show that the output of the basal ganglia fully controls active avoidance behavior. |
| Databáze: | OpenAIRE |
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