Cingulate and thalamic metabolites in obsessive-compulsive disorder
| Autor: | Jeffry R. Alger, Joseph O'Neill, Courtney Sheen, Casey C. Armstrong, Ronald Ly, Susanna Chang, Jennifer G. Levitt, Noriko Salamon, Giulia Salgari, Tsz M. Lai, Jamie D. Feusner |
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| Rok vydání: | 2015 |
| Předmět: |
Cingulate cortex
Adult Male medicine.medical_specialty Obsessive-Compulsive Disorder Proton Magnetic Resonance Spectroscopy Clinical Sciences Thalamus Neuroscience (miscellaneous) Creatine Gyrus Cinguli Article Phosphocreatine 03 medical and health sciences chemistry.chemical_compound Glutamatergic 0302 clinical medicine Clinical Research Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Depression (differential diagnoses) Anterior cingulate cortex Psychiatry Depression Neurosciences Glutamate receptor Middle Aged Anxiety Disorders Brain Disorders 030227 psychiatry Psychiatry and Mental health Mental Health Endocrinology medicine.anatomical_structure chemistry Cognitive Sciences Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | O'Neill, J; Lai, TM; Sheen, C; Salgari, GC; Ly, R; Armstrong, C; et al.(2016). Cingulate and thalamic metabolites in obsessive-compulsive disorder. PSYCHIATRY RESEARCH-NEUROIMAGING, 254, 34-40. doi: 10.1016/j.pscychresns.2016.05.005. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9157t6b3 |
| ISSN: | 1872-7506 |
| DOI: | 10.1016/j.pscychresns.2016.05.005. |
| Popis: | Focal brain metabolic effects detected by proton magnetic resonance spectroscopy (MRS) in obsessive-compulsive disorder (OCD) represent prospective indices of clinical status and guides to treatment design. Sampling bilateral pregenual anterior cingulate cortex (pACC), anterior middle cingulate cortex (aMCC), and thalamus in 40 adult patients and 16 healthy controls, we examined relationships of the neurometabolites glutamate+glutamine (Glx), creatine+phosphocreatine (Cr), and choline-compounds (Cho) with OCD diagnosis and multiple symptom types. The latter included OC core symptoms (Yale-Brown Obsessive-Compulsive Scale - YBOCS), depressive symptoms (Montgomery-Åsberg Depression Rating Scale - MADRS), and general functioning (Global Assessment Scale - GAS). pACC Glx was 9.7% higher in patients than controls. Within patients, Cr and Cho correlated negatively with YBOCS and MADRS, while Cr correlated positively with the GAS. In aMCC, Cr and Cho correlated negatively with MADRS, while Cr in thalamus correlated positively with GAS. These findings present moderate support for glutamatergic and cingulocentric perspectives on OCD. Based on our prior metabolic model of OCD, we offer one possible interpretation of these group and correlational effects as consequences of a corticothalamic state of elevated glutamatergic receptor activity alongside below-normal glutamatergic transporter activity. |
| Databáze: | OpenAIRE |
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