Studies on MCM-41 mesoporous silica for drug delivery: Effect of particle morphology and amine functionalization
| Autor: | Montserrat Colilla, Miguel Manzano, Francisco Balas, Valentina Alice Cauda, María Vallet-Regí, M. Delgado, C. Arean, V. Aina |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Materials science
General Chemical Engineering Nanotechnology General Chemistry Mesoporous silica Grafting Ibuprofen Industrial and Manufacturing Engineering Silica-based mesoporous materials Drug delivery systems MCM-41 Chemical engineering Drug delivery medicine Environmental Chemistry Particle Surface modification Mesoporous material medicine.drug |
| Popis: | Mesoporous MCM-41 silica functionalized by 3-aminopropyltriethoxysilane grafting was studied as a potential carrier for controlled drug release, using ibuprofen as a test drug. For comparison, non-functionalized MCM-41 was also investigated. For the purpose of testing the effect of carrier morphology on drug delivery rate, MCM-41 was prepared in the form of both, a powder consisting of irregularly shaped (and sized) particles and monodispersed spheres (490 to 770 nm in diameter). Amine-functionalized MCM-41 micro-spheres were found to show a significantly slower drug release rate than irregularly shaped powders, which should facilitate drug delivery control over a longer time period. |
| Databáze: | OpenAIRE |
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