The metabolism and excretion of [14C] 2- and 4-chlorobenzoic acids in the rat
| Autor: | C. A. Blackledge, Jeremy K. Nicholson, Ian D. Wilson, E.A Partridge |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Magnetic Resonance Spectroscopy Metabolite Clinical Biochemistry Glycine Pharmaceutical Science Urine Mass Spectrometry Analytical Chemistry Excretion Feces chemistry.chemical_compound Pharmacokinetics Internal medicine Drug Discovery medicine Animals Spectroscopy Nuclear magnetic resonance spectroscopy Metabolism Rats Chlorobenzoates Endocrinology chemistry Biochemistry Chromatography Thin Layer Quantitative analysis (chemistry) Injections Intraperitoneal |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 22:1023-1028 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/s0731-7085(00)00295-8 |
| Popis: | The metabolic fate of [14C]-labelled 2 and 4-chlorobenzoic acids (2- and 4-CBA) has been determined in the rat following intraperitoneal (i.p.) administration at 100 mg/kg to male rats. The major route of elimination for both 2-and 4-CBA was urine with > 80%, of the dose recovered in the initial 0-24 h after administration. Glycine conjugation was found to be the dominant metabolic fate for both [14C] 2- and 4-CBA however, the position of chloro substitution had a clear effect on the extent of metabolism via this route with ortho substitution reducing the extent of metabolism via this pathway. |
| Databáze: | OpenAIRE |
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