Solanidine is Present in Sera of Healthy Individuals and in Amounts Dependent on their Dietary Potato Consumption
| Autor: | M. McMillan, H. W. S. Chan, M.H. Harvey, Michael R. A. Morgan |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Time Factors Adolescent Health Toxicology and Mutagenesis Diosgenin Toxicology Solanaceous Alkaloids 030226 pharmacology & pharmacy Biological fluid Solanidine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Vegetables Humans 030212 general & internal medicine Food science chemistry.chemical_classification biology Alkaloid Glycoside Middle Aged biology.organism_classification Diet chemistry Biochemistry Healthy individuals Toxicity Female Steroidal alkaloid Solanaceae |
| Zdroj: | Human Toxicology. 4:187-194 |
| ISSN: | 0144-5952 |
| DOI: | 10.1177/096032718500400209 |
| Popis: | 1 Solanidine, a steroidal alkaloid, and its glycosides have been reported to have caused poisoning in man and animals. These alkaloids are normally present in small amounts in potatoes. Measurement of solanidine in body fluid would be expected to establish the real incidence of acute toxicity and help to resolve the question of any chronic toxicity including teratogenicity. 2 We report the detection of solanidine in the serum of 57 normal healthy volunteer subjects in whom it measured 4.0-56.3 nmol/l (1.6-22.5 ng/ml) before the midday meal. There was a significant correlation between serum solanidine concentration and normal dietary intake of potato by the individual concerned. 3 When two subjects abstained from potato and its products serum solanidine fell markedly and became minimal after the second week onwards. |
| Databáze: | OpenAIRE |
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