Does Sugammadex Suppress Allergic Inflammation Due to Rocuronium in Animal Model of Rat?
| Autor: | Melek Güra Çelik, Mahmut Dogru, Hasan Cakır, Serdar Yeşiltaş, Zeynep Nur Orhon |
|---|---|
| Přispěvatelé: | YEŞİLTAŞ, SERDAR |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Allergy Immunology Hemorrhage Immunoglobulin E Gastroenterology Sugammadex Allergic inflammation Rats Sprague-Dawley Random Allocation Internal medicine medicine Hypersensitivity Immunology and Allergy Animals Lymphocytes Mast Cells Rocuronium skin and connective tissue diseases Anaphylaxis Lung Inflammation biology business.industry General Medicine medicine.disease Pathophysiology Rats Pulmonary Alveoli Disease Models Animal medicine.anatomical_structure C-Reactive Protein YEŞİLTAŞ S. Orhon Z. N. Cakir H. Dogru M. Celik M. G. -Does Sugammadex Suppress Allergic Inflammation Due to Rocuronium in Animal Model of Rat?- ALLERGOLOGIA ET IMMUNOPATHOLOGIA cilt.49 sa.3 ss.91-99 2021 biology.protein Tryptases sense organs business medicine.drug Neuromuscular Nondepolarizing Agents |
| Zdroj: | Allergologia et immunopathologia. 49(3) |
| ISSN: | 1578-1267 |
| Popis: | Introduction and Objectives: There are a few reports in the literature about the successful use of sugammadex in the treatment of hypersensitivity reactions caused by rocuronium; however, the pathophysiological mechanism is still unknown. This study aims to investigate the changes caused by rocuronium in the lung and the effect of sugammadex on these changes with bio-chemical, light microscopic and immunohistochemical parameters on a rat model.Materials and Methods: For the study, 28-male Sprague-Dawley rats were randomly divided, seven of each, into four groups. Group C (control) received only 0. 9 % NaCl without any drug. Group R received rocuronium alone 1mg/kg. Group S received sugammadex alone 96 mg/kg. Group RS received rocuronium 1mg/kg and sugammadex 96 mg/kg. After 24 h later, the ani-mals were sacrificed and their tissues were removed. Biochemical (IgE/CRP), light microscopic and immunohistochemical findings were recorded.Results: Immunoglobulin E and CRP levels, peribronchial, alveolar septal lymphocytic infiltra-tion, thickening of the alveolar membranes and bleeding sites in Group R were significantly higher than all the other groups. In Group RS, while these parameters were significantly lower than that of Group R and Group S, it was significantly higher than that of Group C. Total mast cells and tryptase-positive mast cells counts were significantly higher in Group R than in all other groups. In Group RS, these parameters were statistically lower than that of Group R and Group S, but higher than that of Group C.Conclusions: This study shows that allergic inflammatory changes due to rocuronium in the lungs of rats are reduced with sugammadex. These results support cases of anaphylaxis due to rocuronium which improved with sugammadex. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|