Successful Treatment of a Paroxysmal Kinesigenic Dyskinesia Patient with Carbamazepine-Induced Stevens-Johnson Syndrome Using Oxcarbazepine Monotherapy: A Case Report
| Autor: | Hung T Tran, Laurent Vercueil, Khang Vinh Nguyen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Movement disorders business.industry Antiepileptic drugs Carbamazepine Paroxysmal dyskinesia Stevens-Johnson syndrome Abnormal involuntary movement Case report medicine Psychogenic disease Paroxysmal kinesigenic dyskinesia Medical history Neurology (clinical) Levetiracetam Neurology. Diseases of the nervous system medicine.symptom Oxcarbazepine business RC346-429 medicine.drug Single Case − General Neurology |
| Zdroj: | Case Reports in Neurology Case Reports in Neurology, Vol 13, Iss 3, Pp 598-604 (2021) |
| ISSN: | 1662-680X |
| Popis: | Paroxysmal kinesigenic dyskinesia (PKD) is a rare condition characterized by abnormal involuntary movements that are precipitated by a sudden movement. PKD is often misdiagnosed with psychogenic movement disorders. Carbamazepine is usually the first choice of medication due to its well-established evidence but could induce Stevens-Johnson syndrome. We report a 21-year-old male patient with PKD referred to our movement disorders clinic after being misdiagnosed with conversion syndrome. PRRT2 gene testing using next-generation sequencing revealed a mutation in c.649dupC p. (Arg217fs). The patient responded well to carbamazepine but had to withdraw the treatment due to carbamazepine-induced Stevens-Johnson syndrome after 3 weeks of medication. Our patient did not respond to trials of levetiracetam and phenytoin but finally responded well to oxcarbazepine. The patient was followed up for 4 years, during which he had no attacks and no side effects. Here, we present a PKD case with carbamazepine-induced Stevens-Johnson syndrome successfully treated with oxcarbazepine despite the risk of cross-reactive skin eruption between these antiepileptics. Careful history taking and examining patient’s attacks are crucial to accurate diagnosis and treatment in PKD patients. |
| Databáze: | OpenAIRE |
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