T-Cell Mediated Inflammation in Postmenopausal Osteoporosis
| Autor: | Ajit Perla, Elena Shashkova, Rajeev Aurora, Aditya Katyal, Di Wu, Anna Cline-Smith |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chronic inflammation T-Lymphocytes Osteoimmunology Immunology Osteoporosis Anti-Inflammatory Agents 030209 endocrinology & metabolism Inflammation Context (language use) Review Bioinformatics Bone and Bones Bone resorption Metabolic bone disease postmenopausal osteoporosis 03 medical and health sciences Anabolic Agents 0302 clinical medicine estrogen loss medicine Animals Humans Immunology and Allergy Osteoporosis Postmenopausal osteoimmunology Bone Density Conservation Agents business.industry T cell Estrogens RC581-607 medicine.disease Acquired immune system Menopause 030104 developmental biology Female Bone Remodeling Inflammation Mediators Immunologic diseases. Allergy medicine.symptom business Signal Transduction |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| Popis: | Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone resorption that leads to low bone mass, compromised microarchitecture and structural deterioration that increases the likelihood of fracture with minimal trauma, known as fragility fractures. Several factors contribute to osteoporosis in men and women. In women, menopause – the cessation of ovarian function, is one of the leading causes of primary osteoporosis. Over the past three decades there has been growing appreciation that the adaptive immune system plays a fundamental role in the development of postmenopausal osteoporosis, both in humans and in mouse models. In this review, we highlight recent data on the interactions between T cells and the skeletal system in the context of postmenopausal osteoporosis. Finally, we review recent studies on the interventions to ameliorate osteoporosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|