Inflammation as a possible link between coronary and carotid plaque instability
| Autor: | Antonella Lombardo, Francesco Burzotta, Pasquale Silvestri, Giovanna Liuzzo, Luigi M. Biasucci, Stefano Coli, Gaetano Antonio Lanza, Attilio Maseri, Filippo Crea, Domenico Cianflone |
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| Přispěvatelé: | Lombardo, A, Biasucci, Lm, Lanza, Ga, Coli, S, Silvestri, P, Cianflone, Domenico, Liuzzo, G, Burzotta, F, Crea, F, Maseri, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Carotid Artery Diseases
medicine.medical_specialty Comorbidity Unstable Angina Pectoris Angina plaque carotid arteries Risk Factors Physiology (medical) Internal medicine medicine Prevalence Humans Angina Unstable Prospective Studies Prospective cohort study Aged Retrospective Studies Ultrasonography Inflammation business.industry Retrospective cohort study Middle Aged medicine.disease medicine.anatomical_structure C-Reactive Protein Bypass surgery Circulatory system Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE Cardiology Cardiology and Cardiovascular Medicine business Biomarkers Blood vessel Artery |
| Zdroj: | Scopus-Elsevier |
| Popis: | Background— Multiple complex stenoses, plaque fissures, and widespread coronary inflammation are common in acute coronary syndromes. A systemic cause of atherosclerotic plaque instability is also suggested by studies of ischemic cerebrovascular disease. We investigated the association between coronary and carotid plaque instability and the potential common causal role of inflammation. Methods and Results— The ultrasound characteristics of carotid plaques were evaluated retrospectively in patients scheduled for coronary bypass surgery, 181 with unstable and 92 with stable angina, and prospectively in a similar group of patients, 67 with unstable and 25 with stable angina, in whom serum C-reactive protein levels were also measured. The prevalence of carotid plaques was similar in the retrospective and prospective studies and >64% in both unstable and stable coronary patients. The prevalence of complex, presumably unstable carotid plaques was 23.2% in unstable versus 3.2% in stable patients ( P P =0.002) in the prospective study. C-reactive protein levels were higher in patients with complex (7.55 mg/L) than in those with simple (3.94 mg/L; P P 3 mg/L were independently associated with complex carotid plaques (OR, 6.09; 95% CI, 1.01 to 33.72; P =0.039, and OR, 5.80; 95% CI, 1.55 to 21.69; P =0.009, respectively). Conclusions— In unstable angina, plaque instability may not be confined to coronary arteries, and inflammation may be the common link with carotid plaque instability. These observations may have relevant implications for understanding the mechanisms of acute widespread atherothrombotic plaque inflammation. |
| Databáze: | OpenAIRE |
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