Protein acylation links metabolism and the control of signal transduction, transcription regulation, growth, and pathogenicity in Actinobacteria

Autor: Zhi‐Yao Peng, Yu Fu, Liu‐Chang Zhao, Yu‐Qi Dong, Zong‐Qin Chen, Di You, Bang‐Ce Ye
Rok vydání: 2022
Předmět:
Zdroj: Molecular Microbiology. 119:151-160
ISSN: 1365-2958
0950-382X
DOI: 10.1111/mmi.14998
Popis: Actinobacteria have a complex life cycle, including morphological and physiological differentiation which are often associated with the biosynthesis of secondary metabolites. Recently, increased interest in post-translational modifications (PTMs) in these Gram-positive bacteria has highlighted the importance of PTMs as signals that provide functional diversity and regulation by modifying proteins to respond to diverse stimuli. Here, we review the developments in research on acylation, a typical PTM that uses acyl-CoA or related metabolites as donors, as well as the understanding of the direct link provided by acylation between cell metabolism and signal transduction, transcriptional regulation, cell growth, and pathogenicity in Actinobacteria.
Databáze: OpenAIRE
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