Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis
| Autor: | Lynn G. Hannum, Ann M. Haberman, Karen S. Lee, María Colmenares, Stephanie L. Constant, Diane McMahon-Pratt, Peter E. Kima, Mark J. Shlomchik |
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| Rok vydání: | 2000 |
| Předmět: |
Leishmania mexicana
Immunology Fc receptor Antibodies Protozoan Leishmaniasis Cutaneous Mice Transgenic Receptors Fc Mice 03 medical and health sciences 0302 clinical medicine Antigen Cutaneous leishmaniasis parasitic diseases medicine Animals Immunology and Allergy Amastigote 030304 developmental biology Mice Knockout Leishmania Mice Inbred BALB C 0303 health sciences biology pathogenesis Receptors IgG Immunization Passive Brief Definitive Report Leishmaniasis medicine.disease biology.organism_classification Virology infection 3. Good health antigen presentation biology.protein Antibody 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.191.6.1063 |
| Popis: | We show here that maintenance of Leishmania infections with Leishmania mexicana complex parasites (Leishmania amazonensis and Leishmania pifanoi) is impaired in the absence of circulating antibody. In these studies, we used mice genetically altered to contain no circulating antibody, with and without functional B cells. This experimental design allowed us to rule out a critical role for B cell antigen presentation in Leishmania pathogenesis. In addition, we show that mice lacking the common gamma chain of Fc receptors (FcgammaRI, FcepsilonRI, and FcgammaRIII) are similarly refractory to infection with these parasites. These observations establish a critical role for antibody in the pathogenesis associated with infection by members of the L. mexicana complex. |
| Databáze: | OpenAIRE |
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