Effect of Alpha-Naphthyl-Isothiocyanate (ANIT) on rat livers, studied with colchicine and with 3H-thymidine autoradiography
| Autor: | I.S. Levij, H. Ungar |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
medicine.medical_specialty Ductal cells Clinical Biochemistry Alpha (ethology) Biology Tritium Pathology and Forensic Medicine chemistry.chemical_compound Oral administration Internal medicine medicine Animals Colchicine Molecular Biology Mitosis DNA synthesis DNA Rats Endocrinology Liver chemistry Isothiocyanate Autoradiography Bile Ducts Thymidine Cell Division Thiocyanates |
| Zdroj: | Experimental and Molecular Pathology. 6:232-236 |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/0014-4800(67)90058-5 |
| Popis: | Mitotic counts carried out after administration of colchicine and autoradiography with tritiated thymidine show that after oral administration of ANIT to rats, a temporary depression occurs in the process of renewal of hepatocytes, ductal and littoral cells. The very pronounced increase of DNA synthesis and mitotic rate among ductal cells coincides with a marked multiplication of the number of bile ductules. This adds evidence to the view that newly formed bile ductules are derived from proliferation of pre-existing ductal epithelium. |
| Databáze: | OpenAIRE |
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