Biomarkers of exposure to environmental contaminants in French pregnant women from the Elfe cohort in 2011
| Autor: | Stéphanie Vandentorren, Corinne Delamaire, Serge Brunel, Agnès Lefranc, Perrine de Crouy-Chanel, Bénédicte Berat, Clémentine Dereumeaux, Marie Pecheux, Laurence Guldner, Cécile Zaros, Abdesattar Saoudi, Alain Le Tertre |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Longitudinal study Adolescent Phthalic Acids 010501 environmental sciences Dioxins 01 natural sciences Toxicology Young Adult 03 medical and health sciences 0302 clinical medicine Phenols Pregnancy Environmental health Biomonitoring Humans Medicine Longitudinal Studies 030212 general & internal medicine Benzhydryl Compounds Pesticides Child Furans lcsh:Environmental sciences Flame Retardants 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 business.industry Environmental exposure Pesticide Polychlorinated Biphenyls Endocrine disruptor Cohort Biomarker (medicine) Environmental Pollutants Female France Environmental Pollution business Biomarkers Environmental Monitoring |
| Zdroj: | Environment International, Vol 97, Iss, Pp 56-67 (2016) |
| ISSN: | 0160-4120 |
| Popis: | Background: As part of the perinatal component of the French Human Biomonitoring (HBM) program, biomarkers levels of various chemicals have been described among pregnant women having given birth in continental France in 2011 and who have been enrolled in the Elfe cohort (French Longitudinal Study since Childhood). This paper describes the design of the study and provides main descriptive results regarding exposure biomarkers levels. Methods: Exposure biomarkers were measured in biological samples collected at delivery from pregnant women randomly selected among the participants in the clinical and biological component of the Elfe cohort (n = 4145). The geometric mean and percentiles of the levels distribution were estimated for each biomarker. The sampling design was taken into account in order to obtain estimates representative of the French pregnant women in 2011. Results: Results provide a nation-wide representative description of biomarker levels for important environmental contaminants among pregnant women who gave birth in France in 2011. Bisphenol A (BPA), and some metabolites of phthalates, pesticides (mainly pyrethroids), dioxins, furans, polychlorobiphenyls (PCBs), brominated flame retardants (BFRs), perfluorinated compounds (PFCs) and metals (except uranium) were quantified in almost 100% of the pregnant women. Some compounds showed a downward trend compared to previous studies (lead, mercury), but others did not (pyrethroids) and should be further monitored. Conclusion and perspectives: The present results show that French pregnant women are exposed to a wide variety of pollutants, including some that have been banned or restricted in France. Keywords: Biomonitoring, Pregnant women, Environmental exposure, Endocrine disruptor, Metals |
| Databáze: | OpenAIRE |
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