Mitogenomes Reveal Alternative Initiation Codons and Lineage-Specific Gene Order Conservation in Echinoderms
| Autor: | Yong Kit Samuel Chan, Yin Cheong Aden Ip, Danwei Huang, Zheng Bin Randolph Quek, Jia Jin Marc Chang |
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| Rok vydání: | 2020 |
| Předmět: |
Mitochondrial DNA
Codon Initiator AcademicSubjects/SCI01180 Asteroidea Start codon Gene Order Genetics Animals Molecular Biology Gene Discoveries Ecology Evolution Behavior and Systematics mitochondrial gene order translation table Flatworm mitochondrial gene evolution biology AcademicSubjects/SCI01130 Translation (biology) biology.organism_classification Genetic code Order (biology) Echinoderm Evolutionary biology mitochondrial phylogeny Genome Mitochondrial Echinodermata |
| Zdroj: | Molecular Biology and Evolution |
| ISSN: | 1537-1719 |
| Popis: | The mitochondrial genetic code is much more varied than the standard genetic code. The invertebrate mitochondrial code, for instance, comprises six initiation codons, including five alternative start codons. However, only two initiation codons are known in the echinoderm and flatworm mitochondrial code, the canonical ATG and alternative GTG. Here, we analyzed 23 Asteroidea mitogenomes, including ten newly sequenced species and unambiguously identified at least two other start codons, ATT and ATC, both of which also initiate translation of mitochondrial genes in other invertebrates. These findings underscore the diversity of the genetic code and expand upon the suite of initiation codons among echinoderms to avoid erroneous annotations. Our analyses have also uncovered the remarkable conservation of gene order among asteroids, echinoids, and holothuroids, with only an interchange between two gene positions in asteroids over ∼500 Ma of echinoderm evolution. |
| Databáze: | OpenAIRE |
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