Effect of alpha 1-adrenergic blockade on canine ileal water, electrolyte, and glucose absorption
| Autor: | Charles J. Yeo, Jacqueline D. Gontarek, Barry Mk, Pickering Sp |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Absorption of water Physiology Ileum Absorption (skin) Intestinal absorption Norepinephrine (medication) Terazosin Eating Electrolytes Dogs Internal medicine Receptors Adrenergic alpha-1 medicine Animals Phenylephrine Adrenergic alpha-Antagonists biology Chemistry digestive oral and skin physiology Fissipedia Gastroenterology Water Prazosin biology.organism_classification Endocrinology medicine.anatomical_structure Glucose Intestinal Absorption Female medicine.drug |
| Zdroj: | Digestive diseases and sciences. 39(11) |
| ISSN: | 0163-2116 |
| Popis: | Meal ingestion stimulates an increase in small intestinal water and electrolyte absorption. Endogenous norepinephrine may at least partially mediate this meal-stimulated proabsorptive response. Luminally administered alpha 1-adrenergic agonists such as norepinephrine and phenylephrine cause significant small bowel absorption, which can be prevented by the selective alpha 1-adrenergic antagonist terazosin. This study tested two hypotheses: (1) a meal stimulates ileal water, electrolyte, and glucose absorption; and (2) meal-stimulated ileal absorption is mediated via alpha 1-adrenergic receptor activation. Absorption studies (N = 27) were performed on dogs with 25-cm ileal Thirty-Vella fistulas (TVF). Perfusion with [14C]PEG was used to calculate absorption of water, electrolytes, and glucose from the TVF. Three groups were randomly studied over 4 hr: (1) terazosin alone, (2) meal alone, and (3) terazosin plus meal. Terazosin (10(-4) M) was administered to the TVF in groups 1 and 3 following the first hour. A 480-kcal mixed canine meal was ingested at the end of the second hour in groups 2 and 3. Ileal water, electrolyte, and glucose absorption increased significantly in response to meal ingestion (P0.05). Luminal terazosin did not significantly alter basal or meal-stimulated ileal absorption. In conclusion, meal ingestion stimulates ileal absorption of water, electrolytes, and glucose. Neither basal nor meal-stimulated ileal absorption is altered by alpha 1-adrenergic receptor blockade. These data suggest that nonadrenergic neural pathways or humoral factors are the likely mediators of meal-induced intestinal absorption. |
| Databáze: | OpenAIRE |
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