The Association Between Primary Antiretroviral Resistance and HAART Virologic Failure in a Developing Set
| Autor: | Maria Cecília Araripe Sucupira, Marcos Montani Caseiro, Luiz Mario Janini, Dercy Jose de Sa-Filho, Ricardo Sobhie Diaz, Wagner T. Alkmim Maia, Luiz Henrique Gagliani |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male medicine.medical_specialty Demographics Anti-HIV Agents Immunology Population Human immunodeficiency virus (HIV) HIV Infections Microbial Sensitivity Tests CD8-Positive T-Lymphocytes medicine.disease_cause Antiretroviral Therapy Highly Active Virology Internal medicine Drug Resistance Viral medicine Humans education Biological sciences Aged Retrospective Studies Aged 80 and over High rate education.field_of_study business.industry Hiv incidence virus diseases Middle Aged Viral Load CD4 Lymphocyte Count VIROLOGIC FAILURE Infectious Diseases Case-Control Studies Mutation HIV-1 Female business Viral load Brazil |
| Zdroj: | AIDS Research and Human Retroviruses. 27:251-256 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2010.0150 |
| Popis: | Santos is a Brazilian port city with high HIV incidence, high primary antiretroviral resistance levels, high HIV-1 BF recombinants prevalence, and high rates of antiretroviral virologic failure. We evaluated factors related to virologic failure after 48 weeks of HAART in this population. We compared demographic and HIV profiles among 43 individuals with virologic failure (group 1) and 37 with virologic success (group 2) after 48 weeks of HAART initiation. The overall primary antiretroviral resistance prevalence was 31.2%; 46.5% in group 1 and 13.5% in group 2 (p 0.005). Nine patients from group 1 and seven from group 2 were infected by F or BF strains. Fifteen individuals presented with NRTI mutations, 13 with NNRTI mutations, three with PI mutations, and five with NRTI and NNRTI mutations. No significant differences were observed in baseline viral load, CD4, clade assignment, antiretrovirals used, or demographics among groups or patients harboring resistant versus wild-type viruses. In this region, there was a high prevalence of antiretroviral resistance among long standing infected patients whose disease had progressed. This finding supports the concept that resistance testing prior to ART initiation is cost effective. The association between primary antiretroviral resistance and virologic failure may suggest that primary resistance greatly impairs antiretroviral activity. |
| Databáze: | OpenAIRE |
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